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Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction.

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Date
2017-01
Authors
Hemmersbach-Miller, M
Duronville, J
Sethi, S
Miller, SE
Howell, DN
Henshaw, N
Alexander, BD
Roberts, JK
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Abstract
Interstitial nephritis due to viruses is well-described after solid organ transplantation. Viruses implicated include cytomegalovirus; BK polyomavirus; Epstein-Barr virus; and, less commonly, adenovirus. We describe a rare case of hemorrhagic allograft nephritis due to herpes simplex virus type 1 at 10 days after living donor kidney transplantation. The patient had a favorable outcome with intravenous acyclovir and reduction of immunosuppression.
Type
Journal article
Subject
clinical research/practice
donors and donation
infection and infectious agents
infectious disease
kidney disease: infectious
kidney transplantation/nephrology
kidney transplantation: living donor
viral
Permalink
https://hdl.handle.net/10161/13102
Published Version (Please cite this version)
10.1111/ajt.14022
Publication Info
Hemmersbach-Miller, M; Duronville, J; Sethi, S; Miller, SE; Howell, DN; Henshaw, N; ... Roberts, JK (2017). Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction. Am J Transplant, 17(1). pp. 287-291. 10.1111/ajt.14022. Retrieved from https://hdl.handle.net/10161/13102.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Alexander

Barbara Dudley Alexander

Professor of Medicine
Clinical research related to infectious complications of solid organ and bone marrow transplantation, with a particular interest in the treatment and rapid diagnosis of fungal disease. Training the next generation of Transplant Infectious Disease Physicians is a special focus of mine as the Principal Investigator of our Interdisciplinary T32 Training Program funded the NIH. 
Duronville

John V Duronville

Assistant Professor of Medicine
Hemmersbach Miller

Marion Hemmersbach Miller

House Staff
Henshaw

Nancy Gail Henshaw

Assistant Professor of Pathology
RESEARCH ABSTRACT Morphology and pathogenesis of Pneumocystis carinii, rapid viral diagnosis, particularly in the immunocompromised host. Most of my research efforts are of an applied nature which involves adapting new methods of rapid viral diagnosis and testing those newer approaches against standard virological procedures. Validated new tests are incorporated into the standard work-up of appropriate virological specimens. Ultimately the expanded offerings result in a
Howell

David Noble Howell

Professor of Pathology
A major focus of both my clinical practice and investigative work is the diagnosis and treatment of disorders affecting solid-organ transplant recipients, particularly infectious complications. For the past 15 years, I have served as the primary pathologist for one of the largest lung transplant programs in the world; in the process contributing to over 20 peer-reviewed publications on complications of lung transplantation, including infections, gastroesophageal reflux, tumors, and antibod
Miller

Sara Elizabeth Miller

Professor in Pathology
Our laboratory specializes in two areas, infectious diseases, particularlyviral diseases, and ultrastructure-function relationships. Electronmicroscopy (EM) is the focus of the investigative techniques and includes preparative methods such as negative staining, thin sectioning, ultracryomicrotomy and immunolabeling of acrylic and frozen sections. We are especially interested in methods for diagnosing viral illnesses by EM, and are involved in developing better, more sensitive and fa
Roberts

John Keith Roberts

Associate Professor of Medicine
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