Prevalence of renal anomalies after urinary tract infections in hospitalized infants less than 2 months of age.
Abstract
OBJECTIVE: Our aim was to determine the incidence of anatomical abnormalities after
a urinary tract infection (UTI) in infants <2 months of age hospitalized in the neonatal
intensive care unit (NICU). STUDY DESIGN: This was a retrospective, single-center
cohort study of infants <2 months of age in the NICU with a UTI and documented renal
imaging. RESULT: We identified 141 infants with UTIs. The mean gestational age and
birth weight were 28 weeks and 1254 g, respectively. The most commonly identified
pathogen was coagulase-negative Staphylococcus (28%, 44 of 156). A major abnormality
was found on at least one imaging study for 4% (5 of 118) of infants. Major abnormalities
were noted on 4% (5 of 114) of renal ultrasounds and 2% (2 of 82) of voiding cystourethrography
examinations. CONCLUSION: Among infants in the NICU <2 months of age at the time of
a UTI, the prevalence of major anatomical abnormalities is <5%.
Type
Journal articleSubject
Academic Medical CentersFemale
Humans
Hydronephrosis
Infant
Infant, Newborn
Intensive Care Units, Neonatal
Male
North Carolina
Prevalence
Ultrasonography
Urinary Tract Infections
Urogenital Abnormalities
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https://hdl.handle.net/10161/13144Published Version (Please cite this version)
10.1038/jp.2009.147Publication Info
(2010). Prevalence of renal anomalies after urinary tract infections in hospitalized infants
less than 2 months of age. J Perinatol, 30(4). pp. 281-285. 10.1038/jp.2009.147. Retrieved from https://hdl.handle.net/10161/13144.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Barbara Dudley Alexander
Professor of Medicine
Clinical research related to infectious complications of solid organ and bone marrow
transplantation, with a particular interest in the treatment and rapid diagnosis of
fungal disease. Training the next generation of Transplant Infectious Disease Physicians
is a special focus of mine as the Principal Investigator of our Interdisciplinary
T32 Training Program funded the NIH.
Charles Michael Cotten
Professor of Pediatrics
I am involved in 4 major areas of research: 1) Neuroprotection. Working with colleagues
from Cell Therapies, we have added to Duke's experience participating in pivotal trials
of hypothermia for term newborns with moderate to severe hypoxic-ischemic encephalopathy
(HIE) by completing a phase I study of autologous cord blood cells for these infants,
and developing and currently leading a multicenter, double-blind randomized clinical
trial of autologous cord blood cells or placebo in te
Patrick Casey Seed
Associate Professor of Pediatrics
We are studying human microbial ecology and the molecular basis for different bacterial
infections that are of relevance to both children and adults. Summaries of the research
areas are described below: 1. THE MOLECULAR BASIS FOR VIRULENCE OF UROPATHOGENIC
ESCHERICHIA COLI AND URINARY TRACT INFECTIONS. Uropathogenic Escherichia coli (UPEC)
is the leading cause of community-acquired urinary tract infections (UTIs). Over
100 million UTIs occur annually throughout the world inclu
Phillip Brian Smith
Samuel L. Katz Distinguished Professor of Pediatrics
Dr. Smith completed his residency in pediatrics and a fellowship in neonatal medicine
at Duke University Medical Center in 2004 and 2007, respectively. He completed an
MHS in clinical research from Duke University in 2006 and an MPH in biostatistics
from the University of North Carolina at Chapel Hill in 2009. His research is focused
on pediatric drug safety, neonatal pharmacology, and the epidemiology of neonatal
infections. Dr. Smith is or has been the protocol chair for more than 14 studie
John Samuel Wiener
Professor of Urology
As a general pediatric urologist, Dr. Wiener is involved with all aspects of pediatric
urology as a clinician and researcher. His research interests are most focused, however,
on the urologic management of neurogenic bladder and spina bifida and the molecular
biology involving development of the genitourinary tract and disorders.Dr. Wiener
is the principal investigator at Duke for The National Spina Bifida Patient Registry
and Urologic Management of Young Children with
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