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L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development.

dc.contributor.author Kaplan, RE
dc.contributor.author Baugh, Ryan
dc.coverage.spatial United States
dc.date.accessioned 2016-12-14T18:48:23Z
dc.date.available 2016-12-14T18:48:23Z
dc.date.issued 2016-04
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/27383290
dc.identifier 1175196
dc.identifier.issn 2162-4046
dc.identifier.uri http://hdl.handle.net/10161/13271
dc.description.abstract Post-embryonic development is governed by nutrient availability. L1 arrest, dauer formation and aging illustrate how starvation, anticipation of starvation and caloric restriction have profound influence on C. elegans development, respectively. Insulin-like signaling through the Forkhead box O transcription factor daf-16/FoxO regulates each of these processes. We recently reported that ins-4, ins-6 and daf-28 promote L1 development from the intestine and chemosensory neurons, similar to their role in dauer development. daf-16 functions cell-nonautonomously in regulation of L1 arrest, dauer development and aging. Discrepancies in daf-16 sites of action have been reported in each context, but the consensus implicates epidermis, intestine and nervous system. We suggest technical limitations of the experimental approach responsible for discrepant results. Steroid hormone signaling through daf-12/NHR is known to function downstream of daf-16 in control of dauer development, but signaling pathways mediating cell-nonautonomous effects of daf-16 in aging and L1 arrest had not been identified. We recently showed that daf-16 promotes L1 arrest by inhibiting daf-12/NHR and dbl-1/TGF-β Sma/Mab signaling, two pathways that promote L1 development in fed larvae. We will review these results on L1 arrest and speculate on why there are so many signals and signaling centers regulating post-embryonic development.
dc.language eng
dc.relation.ispartof Worm
dc.relation.isversionof 10.1080/21624054.2016.1175196
dc.subject FoxO
dc.subject IGF
dc.subject L1 arrest
dc.subject L1 diapause
dc.subject aging
dc.subject daf-12
dc.subject daf-16
dc.subject dauer
dc.subject dbl-1
dc.subject insulin
dc.title L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/27383290
pubs.begin-page e1175196
pubs.issue 2
pubs.organisational-group Biology
pubs.organisational-group Duke
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published online
pubs.volume 5


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