MASTERMIND: Bringing Microbial Diagnostics to the Clinic.
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New diagnostics are urgently needed to address emerging antimicrobial resistance. The Antibacterial Resistance Leadership Group proposes a strategy called MASTERMIND (Master Protocol for Evaluating Multiple Infection Diagnostics) for advancement of infectious diseases diagnostics. The goal of this strategy is to generate the data necessary to support US Food and Drug Administration clearance of new diagnostic tests by promoting research that might not have otherwise been feasible with conventional trial designs. MASTERMIND uses a single subject's sample(s) to evaluate multiple diagnostic tests at the same time, providing efficiencies of specimen collection and characterization. MASTERMIND also offers central trial organization, standardization of methods and definitions, and common comparators.
Published Version (Please cite this version)10.1093/cid/ciw788
Publication InfoAntibacterial Resistance Leadership Group (ARLG); Evans, Scott; Fowler, Vance Garrison Jr; Klausner, JD; Patel, R; Petzold, E; & Tsalik, Ephraim L (2017). MASTERMIND: Bringing Microbial Diagnostics to the Clinic. Clin Infect Dis, 64(3). pp. 355-360. 10.1093/cid/ciw788. Retrieved from http://hdl.handle.net/10161/13292.
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Professor of Medicine
Determinants of Outcome in Patients with Staphylococcus aureus Bacteremia Pathogenesis of Bacterial Infections Infections due to Resistant Gram Positive Organisms Tropical medicine/International Health
Associate Professor of Medicine
My research is focused on understanding the dynamic between host and pathogen so as to discover and develop host-response markers that can diagnose and predict health and disease. This new and evolving approach to diagnosing illness has the potential to significantly impact individual as well as public health considering the rise of antibiotic resistance. With any potential infectious disease diagnosis, it is difficult, if not impossible, to determine at the time of presentation
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