Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.
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Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
Published Version (Please cite this version)10.1093/ofid/ofw042
Publication InfoClement, Meredith; Flores, AR; Fowler, Vance Garrison Jr; Galloway-Peña, J; Levinson, H; Moore, Z; ... Shelburne, SA (2016). Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease. Open Forum Infect Dis, 3(1). pp. ofw042. 10.1093/ofid/ofw042. Retrieved from http://hdl.handle.net/10161/13304.
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Professor of Medicine
Determinants of Outcome in Patients with Staphylococcus aureus Bacteremia Pathogenesis of Bacterial Infections Infections due to Resistant Gram Positive Organisms Tropical medicine/International Health
Associate Professor of Surgery
Fibrosis Wound Healing Cell Contractility Tissue RemodelingMedical device development including hernia mesh, tissue engineered skin and wound care technologies
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