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Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins.

dc.contributor.author Andersen, Paal Skytt
dc.contributor.author Pedersen, Jacob Krabbe
dc.contributor.author Fode, Peder
dc.contributor.author Skov, Robert L
dc.contributor.author Fowler, Vance G
dc.contributor.author Stegger, Marc
dc.contributor.author Christensen, Kaare
dc.coverage.spatial United States
dc.date.accessioned 2017-01-01T20:14:32Z
dc.date.issued 2012-10
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/22872733
dc.identifier jis491
dc.identifier.uri https://hdl.handle.net/10161/13326
dc.description.abstract BACKGROUND: Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, one-quarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown. METHODS: Nasal swabs were obtained from a national cohort of middle-aged and elderly Danish twins. Subjects colonized with S. aureus were identified by growth on selective plates and spa typing. A second sample was obtained from twins initially concordant for carriage. Twins found to again be colonized with S. aureus were defined as persistent carriers. RESULTS: The prevalence of S. aureus carriage among 617 twin pairs (monozygotic/dizygotic pairs: 112/505) was 26.3% (95% confidence interval [CI], 24.0%-28.9%). The concordance rate for carriage did not differ significantly between pairs of monozygotic (37.5%; 95% CI, 22.3%-53.8%) twins and same sex (24.2%; 95% CI, 15.4%-34.5%), and opposite sex (21.4%; 95% CI, 12.0%-33.4%) dizygotic twins. Despite shared childhoods, only 1 of 617 pairs was concordant with respect to lineage. Although heritability increased for S. aureus and lineage persistency, no significant heritability was detected. CONCLUSION: In this study, host genetic factors exhibited only a modest influence on the S. aureus carrier state of middle-aged and elderly individuals.
dc.language eng
dc.publisher Oxford University Press (OUP)
dc.relation.ispartof J Infect Dis
dc.relation.isversionof 10.1093/infdis/jis491
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Carrier State
dc.subject Denmark
dc.subject Environmental Microbiology
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Molecular Typing
dc.subject Prevalence
dc.subject Staphylococcal Infections
dc.subject Staphylococcus aureus
dc.subject Twins
dc.title Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins.
dc.type Journal article
duke.contributor.id Fowler, Vance G|0025542
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/22872733
pubs.begin-page 1178
pubs.end-page 1184
pubs.issue 8
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Infectious Diseases
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 206
dc.identifier.eissn 1537-6613


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