Prefrontal contributions to relational encoding in amnestic mild cognitive impairment.
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Relational memory declines are well documented as an early marker for amnestic mild cognitive impairment (aMCI). Episodic memory formation relies on relational processing supported by two mnemonic mechanisms, generation and binding. Neuroimaging studies using functional magnetic resonance imaging (fMRI) have primarily focused on binding deficits which are thought to be mediated by medial temporal lobe dysfunction. In this study, prefrontal contributions to relational encoding were also investigated using fMRI by parametrically manipulating generation demands during the encoding of word triads. Participants diagnosed with aMCI and healthy control subjects encoded word triads consisting of a category word with either, zero, one, or two semantically related exemplars. As the need to generate increased (i.e., two- to one- to zero-link triads), both groups recruited a core set of regions associated with the encoding of word triads including the parahippocampal gyrus, superior temporal gyrus, and superior parietal lobule. Participants diagnosed with aMCI also parametrically recruited several frontal regions including the inferior frontal gyrus and middle frontal gyrus as the need to generate increased, whereas the control participants did not show this modulation. While there is some functional overlap in regions recruited by generation demands between the groups, the recruitment of frontal regions in the aMCI participants coincides with worse memory performance, likely representing a form of neural inefficiency associated with Alzheimer's disease.
Mild cognitive impairment
Aged, 80 and over
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Published Version (Please cite this version)10.1016/j.nicl.2016.01.008
Publication InfoFoster, Chris; Addis, Donna; Ford, Jaclyn; Kaufer, Daniel; Browndyke, Jeffrey; Welsh-Bohmer, Kathleen; & Giovanello, Kelly (2016). Prefrontal contributions to relational encoding in amnestic mild cognitive impairment. Neuroimage Clin, 11. pp. 158-166. 10.1016/j.nicl.2016.01.008. Retrieved from https://hdl.handle.net/10161/13328.
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Associate Professor of Psychiatry and Behavioral Sciences
Dr. Browndyke is an Associate Professor of Behavioral Health & Neurosciences in the Department of Psychiatry & Behavioral Sciences. He has a secondary appointment as Assistant Professor of Cardiovascular & Thoracic Surgery.Dr. Browndyke's research interests involve the use of advanced neurocognitive and neuroimaging techniques for perioperative contributions to delirium and later dementia risk, monitoring of late-life neuropathological disease progression, and inter