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Prefrontal contributions to relational encoding in amnestic mild cognitive impairment.

dc.contributor.author Addis, DR
dc.contributor.author Browndyke, Jeffrey Nicholas
dc.contributor.author Burke, JR
dc.contributor.author Ford, JH
dc.contributor.author Foster, CM
dc.contributor.author Giovanello, Kelly S
dc.contributor.author Kaufer, DI
dc.contributor.author Welsh-Bohmer, Kathleen Anne
dc.coverage.spatial Netherlands
dc.date.accessioned 2017-01-01T22:33:01Z
dc.date.issued 2016
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26937384
dc.identifier S2213-1582(16)30007-9
dc.identifier.uri https://hdl.handle.net/10161/13328
dc.description.abstract Relational memory declines are well documented as an early marker for amnestic mild cognitive impairment (aMCI). Episodic memory formation relies on relational processing supported by two mnemonic mechanisms, generation and binding. Neuroimaging studies using functional magnetic resonance imaging (fMRI) have primarily focused on binding deficits which are thought to be mediated by medial temporal lobe dysfunction. In this study, prefrontal contributions to relational encoding were also investigated using fMRI by parametrically manipulating generation demands during the encoding of word triads. Participants diagnosed with aMCI and healthy control subjects encoded word triads consisting of a category word with either, zero, one, or two semantically related exemplars. As the need to generate increased (i.e., two- to one- to zero-link triads), both groups recruited a core set of regions associated with the encoding of word triads including the parahippocampal gyrus, superior temporal gyrus, and superior parietal lobule. Participants diagnosed with aMCI also parametrically recruited several frontal regions including the inferior frontal gyrus and middle frontal gyrus as the need to generate increased, whereas the control participants did not show this modulation. While there is some functional overlap in regions recruited by generation demands between the groups, the recruitment of frontal regions in the aMCI participants coincides with worse memory performance, likely representing a form of neural inefficiency associated with Alzheimer's disease.
dc.language eng
dc.relation.ispartof Neuroimage Clin
dc.relation.isversionof 10.1016/j.nicl.2016.01.008
dc.subject Aging
dc.subject Functional MRI
dc.subject Mild cognitive impairment
dc.subject Relational memory
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Alzheimer Disease
dc.subject Amnesia
dc.subject Cognitive Dysfunction
dc.subject Female
dc.subject Humans
dc.subject Image Processing, Computer-Assisted
dc.subject Magnetic Resonance Imaging
dc.subject Male
dc.subject Memory, Episodic
dc.subject Nerve Net
dc.subject Neuropsychological Tests
dc.subject Prefrontal Cortex
dc.title Prefrontal contributions to relational encoding in amnestic mild cognitive impairment.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26937384
pubs.begin-page 158
pubs.end-page 166
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke-UNC Center for Brain Imaging and Analysis
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurology
pubs.organisational-group Neurology, Behavioral Neurology
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published online
pubs.volume 11
dc.identifier.eissn 2213-1582


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