A wirelessly controlled implantable LED system for deep brain optogenetic stimulation.
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In recent years optogenetics has rapidly become an essential technique in neuroscience. Its temporal and spatial specificity, combined with efficacy in manipulating neuronal activity, are especially useful in studying the behavior of awake behaving animals. Conventional optogenetics, however, requires the use of lasers and optic fibers, which can place considerable restrictions on behavior. Here we combined a wirelessly controlled interface and small implantable light-emitting diode (LED) that allows flexible and precise placement of light source to illuminate any brain area. We tested this wireless LED system in vivo, in transgenic mice expressing channelrhodopsin-2 in striatonigral neurons expressing D1-like dopamine receptors. In all mice tested, we were able to elicit movements reliably. The frequency of twitches induced by high power stimulation is proportional to the frequency of stimulation. At lower power, contraversive turning was observed. Moreover, the implanted LED remains effective over 50 days after surgery, demonstrating the long-term stability of the light source. Our results show that the wireless LED system can be used to manipulate neural activity chronically in behaving mice without impeding natural movements.
Published Version (Please cite this version)10.3389/fnint.2015.00008
Publication InfoRossi, Mark A; Go, Vinson; Murphy, Tracy; Fu, Quanhai; Morizio, James; & Yin, Henry H (2015). A wirelessly controlled implantable LED system for deep brain optogenetic stimulation. Front Integr Neurosci, 9. pp. 8. 10.3389/fnint.2015.00008. Retrieved from https://hdl.handle.net/10161/13450.
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Adjunct Associate Professor in the Department of Electrical and Computer Engineering
Over the last two decades Dr. Morizio's research has been focused on CMOS mixed-signal microelectronics and ASICs used in translational closed-loop, bioelectronic therapies for wireless neural interfaces. These interfaces include sub-system architectures for neural recording and modulation and analog circuits for low noise preamplifier, high channel count multiplexer and programmable current sources. Dr. Morizio's current research is focused on biomedical instrumentation intended
Professor of Psychology and Neuroscience
I am interested in understanding the neural mechanisms underlying goal-directed actions. For the first time in history, advances in psychology and neurobiology have made it feasible to pursue the detailed neural mechanisms underlying goal-directed and voluntary actions--how they are driven by the needs and desires of the organism and controlled by cognitive processes that provide a rich representation of the self and the world. My approach to this problem is highly integrative, combining behav
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