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The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry.

dc.contributor.author Adelsberg, S
dc.contributor.author Anwar, AR
dc.contributor.author Bangaru, S
dc.contributor.author Benedict, MM
dc.contributor.author Biswal, B
dc.contributor.author Brown, S
dc.contributor.author Calhoun, V
dc.contributor.author Castellanos, FX
dc.contributor.author Cheung, B
dc.contributor.author Coffey, B
dc.contributor.author Colcombe, SJ
dc.contributor.author Courtney, W
dc.contributor.author Cox, CL
dc.contributor.author Craddock, CC
dc.contributor.author Di Martino, A
dc.contributor.author Duan, N
dc.contributor.author Gutman, D
dc.contributor.author Hinz, CM
dc.contributor.author Hoptman, MJ
dc.contributor.author Javitt, DC
dc.contributor.author Kamiel, SM
dc.contributor.author Kaplan, MS
dc.contributor.author Kelly, AM
dc.contributor.author Khanuja, R
dc.contributor.author King, M
dc.contributor.author Koplewicz, HS
dc.contributor.author Leventhal, BL
dc.contributor.author Li, Q
dc.contributor.author Mennes, M
dc.contributor.author Milham, MP
dc.contributor.author Moreno, AL
dc.contributor.author Nooner, Kate B
dc.contributor.author Panek, LJ
dc.contributor.author Petkova, E
dc.contributor.author Pomara, N
dc.contributor.author Rachlin, AB
dc.contributor.author Reiss, PT
dc.contributor.author Schlachter, RT
dc.contributor.author Sidtis, JJ
dc.contributor.author Sikka, S
dc.contributor.author Thomsen, D
dc.contributor.author Tobe, RH
dc.contributor.author Wood, D
dc.contributor.author Yan, C
dc.contributor.author Zavitz, ST
dc.coverage.spatial Switzerland
dc.date.accessioned 2017-01-28T23:40:28Z
dc.date.issued 2012
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/23087608
dc.identifier.uri https://hdl.handle.net/10161/13516
dc.description.abstract The National Institute of Mental Health strategic plan for advancing psychiatric neuroscience calls for an acceleration of discovery and the delineation of developmental trajectories for risk and resilience across the lifespan. To attain these objectives, sufficiently powered datasets with broad and deep phenotypic characterization, state-of-the-art neuroimaging, and genetic samples must be generated and made openly available to the scientific community. The enhanced Nathan Kline Institute-Rockland Sample (NKI-RS) is a response to this need. NKI-RS is an ongoing, institutionally centered endeavor aimed at creating a large-scale (N > 1000), deeply phenotyped, community-ascertained, lifespan sample (ages 6-85 years old) with advanced neuroimaging and genetics. These data will be publically shared, openly, and prospectively (i.e., on a weekly basis). Herein, we describe the conceptual basis of the NKI-RS, including study design, sampling considerations, and steps to synchronize phenotypic and neuroimaging assessment. Additionally, we describe our process for sharing the data with the scientific community while protecting participant confidentiality, maintaining an adequate database, and certifying data integrity. The pilot phase of the NKI-RS, including challenges in recruiting, characterizing, imaging, and sharing data, is discussed while also explaining how this experience informed the final design of the enhanced NKI-RS. It is our hope that familiarity with the conceptual underpinnings of the enhanced NKI-RS will facilitate harmonization with future data collection efforts aimed at advancing psychiatric neuroscience and nosology.
dc.language eng
dc.relation.ispartof Front Neurosci
dc.relation.isversionof 10.3389/fnins.2012.00152
dc.subject DTI
dc.subject brain
dc.subject discovery
dc.subject fMRI
dc.subject lifespan
dc.subject open science
dc.subject phenotype
dc.subject psychiatry
dc.title The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/23087608
pubs.begin-page 152
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Psychiatry, Child & Family Mental Health and Developmental Neuroscience
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 6
dc.identifier.eissn 1662-453X


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