Show simple item record

Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis.

dc.contributor.author Uronis, HE
dc.contributor.author Currow, DC
dc.contributor.author McCrory, DC
dc.contributor.author Samsa, GP
dc.contributor.author Abernethy, AP
dc.coverage.spatial England
dc.date.accessioned 2017-03-01T14:18:42Z
dc.date.issued 2008-01-29
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/18182991
dc.identifier 6604161
dc.identifier.issn 0007-0920
dc.identifier.uri https://hdl.handle.net/10161/13711
dc.description.abstract The aim of this study was to determine the efficacy of palliative oxygen for relief of dyspnoea in cancer patients. MEDLINE and EMBASE were searched for randomised controlled trials, comparing oxygen and medical air in cancer patients not qualifying for home oxygen therapy. Abstracts were reviewed and studies were selected using Cochrane methodology. The included studies provided oxygen at rest or during a 6-min walk. The primary outcome was dyspnoea. Standardised mean differences (SMDs) were used to combine scores. Five studies were identified; one was excluded from meta-analysis due to data presentation. Individual patient data were obtained from the authors of the three of the four remaining studies (one each from England, Australia, and the United States). A total of 134 patients were included in the meta-analysis. Oxygen failed to improve dyspnoea in mildly- or non-hypoxaemic cancer patients (SMD=-0.09, 95% confidence interval -0.22 to 0.04; P=0.16). Results were stable to a sensitivity analysis, excluding studies requiring the use of imputed quantities. In this small meta-analysis, oxygen did not provide symptomatic benefit for cancer patients with refractory dyspnoea, who would not normally qualify for home oxygen therapy. Further study of the use of oxygen in this population is warranted given its widespread use.
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof Br J Cancer
dc.relation.isversionof 10.1038/sj.bjc.6604161
dc.subject Aged
dc.subject Algorithms
dc.subject Dyspnea
dc.subject Female
dc.subject Humans
dc.subject Hypoxia
dc.subject Male
dc.subject Neoplasms
dc.subject Oxygen
dc.subject Oxygen Inhalation Therapy
dc.subject Palliative Care
dc.subject Randomized Controlled Trials as Topic
dc.subject Treatment Outcome
dc.title Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis.
dc.type Journal article
duke.contributor.id Uronis, HE|0265192
duke.contributor.id McCrory, DC|0035314
duke.contributor.id Samsa, GP|0110490
duke.contributor.id Abernethy, AP|0050834
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/18182991
pubs.begin-page 294
pubs.end-page 299
pubs.issue 2
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biostatistics & Bioinformatics
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, General Internal Medicine
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Nursing
pubs.organisational-group School of Medicine
pubs.organisational-group School of Nursing
pubs.publication-status Published
pubs.volume 98


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record