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Immunologic Effects of the Renin-Angiotensin System.

dc.contributor.author Crowley, Steven Daniel
dc.contributor.author Rudemiller, Nathan P
dc.coverage.spatial United States
dc.date.accessioned 2017-03-01T16:39:56Z
dc.date.available 2017-03-01T16:39:56Z
dc.date.issued 2017-02-01
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/28151411
dc.identifier ASN.2016101066
dc.identifier.uri http://hdl.handle.net/10161/13735
dc.description.abstract Inappropriate activation of the renin-angiotensin system (RAS) exacerbates renal and vascular injury. Accordingly, treatment with global RAS antagonists attenuates cardiovascular risk and slows the progression of proteinuric kidney disease. By reducing BP, RAS inhibitors limit secondary immune activation responding to hemodynamic injury in the target organ. However, RAS activation in hematopoietic cells has immunologic effects that diverge from those of RAS stimulation in the kidney and vasculature. In preclinical studies, activating type 1 angiotensin (AT1) receptors in T lymphocytes and myeloid cells blunts the polarization of these cells toward proinflammatory phenotypes, protecting the kidney from hypertensive injury and fibrosis. These endogenous functions of immune AT1 receptors temper the pathogenic actions of renal and vascular AT1 receptors during hypertension. By counteracting the effects of AT1 receptor stimulation in the target organ, exogenous administration of AT2 receptor agonists or angiotensin 1-7 analogs may similarly limit inflammatory injury to the heart and kidney. Moreover, although angiotensin II is the classic effector molecule of the RAS, several RAS enzymes affect immune homeostasis independently of canonic angiotensin II generation. Thus, as reviewed here, multiple components of the RAS signaling cascade influence inflammatory cell phenotype and function with unpredictable and context-specific effects on innate and adaptive immunity.
dc.language eng
dc.relation.ispartof J Am Soc Nephrol
dc.relation.isversionof 10.1681/ASN.2016101066
dc.subject hypertension
dc.subject immunology
dc.subject renin angiotensin system
dc.title Immunologic Effects of the Renin-Angiotensin System.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/28151411
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Nephrology
pubs.organisational-group School of Medicine
pubs.publication-status Published online
dc.identifier.eissn 1533-3450


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