COPD: balancing oxidants and antioxidants.
Repository Usage Stats
Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses in the world. The disease encompasses emphysema, chronic bronchitis, and small airway obstruction and can be caused by environmental exposures, primarily cigarette smoking. Since only a small subset of smokers develop COPD, it is believed that host factors interact with the environment to increase the propensity to develop disease. The major pathogenic factors causing disease include infection and inflammation, protease and antiprotease imbalance, and oxidative stress overwhelming antioxidant defenses. In this review, we will discuss the major environmental and host sources for oxidative stress; discuss how oxidative stress regulates chronic bronchitis; review the latest information on genetic predisposition to COPD, specifically focusing on oxidant/antioxidant imbalance; and review future antioxidant therapeutic options for COPD. The complexity of COPD will necessitate a multi-target therapeutic approach. It is likely that antioxidant supplementation and dietary antioxidants will have a place in these future combination therapies.
Gene Expression Regulation
Pulmonary Disease, Chronic Obstructive
Published Version (Please cite this version)10.2147/COPD.S42414
Publication InfoFischer, Bernard Martin; Ghio, Andrew J; & Voynow, JA (2015). COPD: balancing oxidants and antioxidants. Int J Chron Obstruct Pulmon Dis, 10. pp. 261-276. 10.2147/COPD.S42414. Retrieved from https://hdl.handle.net/10161/13742.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
More InfoShow full item record
Associate Professor of Pediatrics
Comparative Pharmacology and Cell Biology Mechanisms of complementary-alternative medicines and products Signal Transduction and Cell Signaling Development of both animal and in vitro models of disease Implications of early life lung injury on long-term immune function and overall health Mechanisms of inflammation and disease Cytokine, Oxidant, and Inflammatory Mediator NetworkingIntegrative care/treatments for HIV patientsMechanisms of chronic inf
Associate Consulting Professor of Medicine
Alphabetical list of authors with Scholars@Duke profiles.