Show simple item record

Epidemiology of Coxiella burnetii infection in Africa: a OneHealth systematic review.

dc.contributor.author Vanderburg, Sky
dc.contributor.author Rubach, Matthew P
dc.contributor.author Halliday, Jo EB
dc.contributor.author Cleaveland, Sarah
dc.contributor.author Reddy, Elizabeth A
dc.contributor.author Crump, John A
dc.coverage.spatial United States
dc.date.accessioned 2017-03-02T19:09:32Z
dc.date.available 2017-03-02T19:09:32Z
dc.date.issued 2014-04
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/24722554
dc.identifier PNTD-D-13-01613
dc.identifier.uri https://hdl.handle.net/10161/13773
dc.description.abstract BACKGROUND: Q fever is a common cause of febrile illness and community-acquired pneumonia in resource-limited settings. Coxiella burnetii, the causative pathogen, is transmitted among varied host species, but the epidemiology of the organism in Africa is poorly understood. We conducted a systematic review of C. burnetii epidemiology in Africa from a "One Health" perspective to synthesize the published data and identify knowledge gaps. METHODS/PRINCIPAL FINDINGS: We searched nine databases to identify articles relevant to four key aspects of C. burnetii epidemiology in human and animal populations in Africa: infection prevalence; disease incidence; transmission risk factors; and infection control efforts. We identified 929 unique articles, 100 of which remained after full-text review. Of these, 41 articles describing 51 studies qualified for data extraction. Animal seroprevalence studies revealed infection by C. burnetii (≤13%) among cattle except for studies in Western and Middle Africa (18-55%). Small ruminant seroprevalence ranged from 11-33%. Human seroprevalence was <8% with the exception of studies among children and in Egypt (10-32%). Close contact with camels and rural residence were associated with increased seropositivity among humans. C. burnetii infection has been associated with livestock abortion. In human cohort studies, Q fever accounted for 2-9% of febrile illness hospitalizations and 1-3% of infective endocarditis cases. We found no studies of disease incidence estimates or disease control efforts. CONCLUSIONS/SIGNIFICANCE: C. burnetii infection is detected in humans and in a wide range of animal species across Africa, but seroprevalence varies widely by species and location. Risk factors underlying this variability are poorly understood as is the role of C. burnetii in livestock abortion. Q fever consistently accounts for a notable proportion of undifferentiated human febrile illness and infective endocarditis in cohort studies, but incidence estimates are lacking. C. burnetii presents a real yet underappreciated threat to human and animal health throughout Africa.
dc.language eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS Negl Trop Dis
dc.relation.isversionof 10.1371/journal.pntd.0002787
dc.subject Africa
dc.subject Animals
dc.subject Community-Acquired Infections
dc.subject Humans
dc.subject Incidence
dc.subject Pneumonia, Bacterial
dc.subject Q Fever
dc.subject Risk Factors
dc.subject Seroepidemiologic Studies
dc.title Epidemiology of Coxiella burnetii infection in Africa: a OneHealth systematic review.
dc.type Journal article
duke.contributor.id Rubach, Matthew P|0562726
duke.contributor.id Reddy, Elizabeth A|0399368
duke.contributor.id Crump, John A|0231646
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/24722554
pubs.begin-page e2787
pubs.issue 4
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Global Health Institute
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Infectious Diseases
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published online
pubs.volume 8
dc.identifier.eissn 1935-2735


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record