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Brucellosis in low-income and middle-income countries.

dc.contributor.author Rubach, MP
dc.contributor.author Halliday, JEB
dc.contributor.author Cleaveland, S
dc.contributor.author Crump, John Andrew
dc.coverage.spatial United States
dc.date.accessioned 2017-03-02T19:12:35Z
dc.date.available 2017-03-02T19:12:35Z
dc.date.issued 2013-10
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/23963260
dc.identifier.uri http://hdl.handle.net/10161/13778
dc.description.abstract PURPOSE OF REVIEW: Human brucellosis is a neglected, underrecognized infection of widespread geographic distribution. It causes acute febrile illness and a potentially debilitating chronic infection in humans, and livestock infection has substantial socioeconomic impact. This review describes new information regarding the epidemiology of brucellosis in the developing world and advances in diagnosis and treatment. RECENT FINDINGS: The highest recorded incidence of human brucellosis occurs in the Middle East and Central Asia. Fever etiology studies demonstrate brucellosis as a cause of undifferentiated febrile illness in the developing world. Brucellosis is a rare cause of fever among returning travelers, but is more common among travelers returning from the Middle East and North Africa. Sensitive and specific rapid diagnostic tests appropriate for resource-limited settings have been validated. Randomized controlled trials demonstrate that optimal treatment for human brucellosis consists of doxycycline and an aminoglycoside. Decreasing the burden of human brucellosis requires control of animal brucellosis, but evidence to inform the design of control programs in the developing world is needed. SUMMARY: Brucellosis causes substantial morbidity in human and animal populations. While improvements in diagnostic options for resource-limited settings and stronger evidence for optimal therapy should enhance identification and treatment of human brucellosis, prevention of human disease through control in animals remains paramount.
dc.language eng
dc.relation.ispartof Curr Opin Infect Dis
dc.relation.isversionof 10.1097/QCO.0b013e3283638104
dc.subject Animals
dc.subject Asia
dc.subject Brucellosis
dc.subject Humans
dc.subject Livestock
dc.subject Middle East
dc.subject Neglected Diseases
dc.subject Socioeconomic Factors
dc.subject Zoonoses
dc.title Brucellosis in low-income and middle-income countries.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/23963260
pubs.begin-page 404
pubs.end-page 412
pubs.issue 5
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Global Health Institute
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Infectious Diseases
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 26
dc.identifier.eissn 1473-6527


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