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Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.

dc.contributor.author Bonsignori, Mattia
dc.contributor.author Montefiori, David C
dc.contributor.author Wu, Xueling
dc.contributor.author Chen, Xi
dc.contributor.author Hwang, Kwan-Ki
dc.contributor.author Tsao, Chun-Yen
dc.contributor.author Kozink, Daniel M
dc.contributor.author Parks, Robert J
dc.contributor.author Tomaras, Georgia D
dc.contributor.author Crump, John A
dc.contributor.author Kapiga, Saidi H
dc.contributor.author Sam, Noel E
dc.contributor.author Kwong, Peter D
dc.contributor.author Kepler, Thomas B
dc.contributor.author Liao, Hua-Xin
dc.contributor.author Mascola, John R
dc.contributor.author Haynes, Barton F
dc.coverage.spatial United States
dc.date.accessioned 2017-03-02T19:17:35Z
dc.date.available 2017-03-02T19:17:35Z
dc.date.issued 2012-04
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/22301150
dc.identifier JVI.07163-11
dc.identifier.uri https://hdl.handle.net/10161/13785
dc.description.abstract Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities.
dc.language eng
dc.publisher American Society for Microbiology
dc.relation.ispartof J Virol
dc.relation.isversionof 10.1128/JVI.07163-11
dc.subject AIDS Vaccines
dc.subject Antibodies, Neutralizing
dc.subject Antibody Specificity
dc.subject Antigens, CD4
dc.subject B-Lymphocytes
dc.subject Binding Sites
dc.subject Epitopes
dc.subject HIV Antibodies
dc.subject HIV Envelope Protein gp120
dc.subject HIV Infections
dc.subject HIV-1
dc.subject Humans
dc.subject Immunoglobulin Variable Region
dc.subject Neutralization Tests
dc.subject Phylogeny
dc.title Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.
dc.type Journal article
duke.contributor.id Bonsignori, Mattia|0383217
duke.contributor.id Montefiori, David C|0099412
duke.contributor.id Tomaras, Georgia D|0204832
duke.contributor.id Crump, John A|0231646
duke.contributor.id Liao, Hua-Xin|0107020
duke.contributor.id Haynes, Barton F|0114780
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/22301150
pubs.begin-page 4688
pubs.end-page 4692
pubs.issue 8
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Human Vaccine Institute
pubs.organisational-group Global Health Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Duke Human Vaccine Institute
pubs.organisational-group Medicine, Infectious Diseases
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group Surgery
pubs.organisational-group Surgery, Surgical Sciences
pubs.organisational-group Surgery, Surgical Sciences Section for AIDS Research & Development
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 86
dc.identifier.eissn 1098-5514
duke.contributor.orcid Bonsignori, Mattia|0000-0003-2973-2101
duke.contributor.orcid Montefiori, David C|0000-0003-0856-6319
duke.contributor.orcid Tomaras, Georgia D|0000-0001-8076-1931


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