A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.
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The treatment of soft tissue sarcoma (STS) generally involves tumor excision with a wide margin. Although advances in fluorescence imaging make real-time detection of cancer possible, removal is limited by the precision of the human eye and hand. Here, we describe a novel pulsed Nd:YAG laser ablation system that, when used in conjunction with a previously described molecular imaging system, can identify and ablate cancer in vivo. Mice with primary STS were injected with the protease-activatable probe LUM015 to label tumors. Resected tissues from the mice were then imaged and treated with the laser using the paired fluorescence-imaging/ laser ablation device, generating ablation clefts with sub-millimeter precision and minimal underlying tissue damage. Laser ablation was guided by fluorescence to target tumor tissues, avoiding normal structures. The selective ablation of tumor implants in vivo improved recurrence-free survival after tumor resection in a cohort of 14 mice compared to 12 mice that received no ablative therapy. This prototype system has the potential to be modified so that it can be used during surgery to improve recurrence-free survival in patients with cancer.
Local Neoplasm Recurrence
Soft Tissue Neoplasms
Published Version (Please cite this version)10.7150/thno.13536
Publication InfoLazarides, Alexander; Whitley, Melodi; Strasfeld, DB; Cardona, Diana Marcella; Ferrer, JM; Mueller, Jenna; ... Eward, William Curtis (2016). A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma. Theranostics, 6(2). pp. 155-166. 10.7150/thno.13536. Retrieved from http://hdl.handle.net/10161/13883.
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Associate Professor of Orthopaedic Surgery
Associate Professor of Pathology
I am active in translational research involving gastrointestinal/hepatobiliary pathology [specifically transplant related pathology (GVHD and rejection) and carcinogenesis of the pancreas] and bone and soft tissue malignancies [imaging techniques for intraoperative margin assessment].
Assistant Professor of Orthopaedic Surgery
I am an Orthopaedic Oncologist, with dual clinical degrees (MD and DVM). I treat complex sarcomas in people and animals. My laboratory studies comparative oncology - discoveries we can make about cancer by analyses across different species.
Barbara Levine University Professor
My clinical interests are the multi-modality care of patients with bone and soft tissue sarcomas and developing new sarcoma therapies. My laboratory interests include utilizing mouse models of cancer to study cancer and radiation biology in order to develop new cancer therapies in the pre-clinical setting.
Robert W. Carr, Jr., Professor of Biomedical Engineering
Dr. Ramanujam is the Robert W. Carr Professor of Biomedical Engineering, and also a faculty member in the Global Health Institute and Dept. Pharmacology and Cell Biology at Duke University. She is an innovator, educator and entrepreneur and her mission is to develop and leverage technology to have the most wide reaching impact in women’s health. She directs the center for Global Women’s Health Technologies (GWHT), a partnership between the Pratt School of Engineering and the Duke
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