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D-Dimer elevation and adverse outcomes.

dc.contributor.author Chi, G
dc.contributor.author Cohen, A
dc.contributor.author Daaboul, Y
dc.contributor.author Gibson, Charles Michael
dc.contributor.author Goldhaber, SZ
dc.contributor.author Halaby, R
dc.contributor.author Harrington, Robert Arthur
dc.contributor.author Hernandez, Adrian Felipe
dc.contributor.author Hull, R
dc.contributor.author Korjian, S
dc.contributor.author Lip, G
dc.contributor.author Martin-Loeches, I
dc.contributor.author Mentz, Robert John
dc.contributor.author Peacock, F
dc.contributor.author Popma, CJ
dc.contributor.author Romero, G
dc.contributor.author Welker, J
dc.contributor.author Zacarkim, MR
dc.coverage.spatial Netherlands
dc.date.accessioned 2017-04-03T14:32:38Z
dc.date.available 2017-04-03T14:32:38Z
dc.date.issued 2015-01
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/25006010
dc.identifier.uri https://hdl.handle.net/10161/13934
dc.description.abstract D-Dimer is a biomarker of fibrin formation and degradation. While a D-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated D-dimer with adverse outcomes has received far less emphasis. An elevated D-dimer is independently associated with an increased risk for incident VTE, recurrent VTE, and mortality. An elevated D-dimer is an independent correlate of increased mortality and subsequent VTE across a broad variety of disease states. Therefore, medically ill subjects in whom the D-dimer is elevated constitute a high risk subgroup in which the prospective evaluation of the efficacy and safety of antithrombotic therapy is warranted.
dc.language eng
dc.relation.ispartof J Thromb Thrombolysis
dc.relation.isversionof 10.1007/s11239-014-1101-6
dc.subject Biomarkers
dc.subject Female
dc.subject Fibrin Fibrinogen Degradation Products
dc.subject Fibrinolytic Agents
dc.subject Humans
dc.subject Male
dc.subject Venous Thromboembolism
dc.subject Venous Thrombosis
dc.title D-Dimer elevation and adverse outcomes.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/25006010
pubs.begin-page 55
pubs.end-page 59
pubs.issue 1
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 39
dc.identifier.eissn 1573-742X


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