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The role of chemokines in hypertension and consequent target organ damage.

dc.contributor.author Crowley, Steven Daniel
dc.contributor.author Rudemiller, Nathan P
dc.coverage.spatial Netherlands
dc.date.accessioned 2017-04-03T14:44:05Z
dc.date.available 2018-04-05T08:17:10Z
dc.date.issued 2017-03-06
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/28279813
dc.identifier S1043-6618(16)31161-6
dc.identifier.uri http://hdl.handle.net/10161/13936
dc.description.abstract Immune cells infiltrate the kidney, vasculature, and central nervous system during hypertension, consequently amplifying tissue damage and/or blood pressure elevation. Mononuclear cell motility depends partly on chemokines, which are small cytokines that guide cells through an increasing concentration gradient via ligation of their receptors. Tissue expression of several chemokines is elevated in clinical and experimental hypertension. Likewise, immune cells have enhanced chemokine receptor expression during hypertension, driving immune cell infiltration and inappropriate inflammation in cardiovascular control centers. T lymphocytes and monocytes/macrophages are pivotal mediators of hypertensive inflammation, and these cells migrate in response to several chemokines. As powerful drivers of diapedesis, the chemokines CCL2 and CCL5 have long been implicated in hypertension, but experimental data highlight divergent, context-specific effects of these chemokines on blood pressure and tissue injury. Several other chemokines, particularly those of the CXC family, contribute to blood pressure elevation and target organ damage. Given the significant interplay and chemotactic redundancy among chemokines during disease, future work must not only describe the actions of individual chemokines in hypertension, but also characterize how manipulating a single chemokine modulates the expression and/or function of other chemokines and their cognate receptors. This information will facilitate the design of precise chemotactic immunotherapies to limit cardiovascular and renal morbidity in hypertensive patients.
dc.language eng
dc.relation.ispartof Pharmacol Res
dc.relation.isversionof 10.1016/j.phrs.2017.02.026
dc.subject Chemokines
dc.subject Hypertension
dc.subject Inflammation
dc.title The role of chemokines in hypertension and consequent target organ damage.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/28279813
pubs.begin-page 404
pubs.end-page 411
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Nephrology
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 119
dc.identifier.eissn 1096-1186


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