Shared features in the pathobiology of babesiosis and malaria.
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The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical times as an important disease of livestock and more recently as an emerging health problem in humans, is caused by related intraerythrocytic protozoa with a similar pathogenesis and clinical course. Recent studies of cytokine activation and erythrocyte cytoadherence in babesiosis and malaria have exploited these similarities to provide new insights into malaria pathobiology. Continued investigation of similarities and differences in the pathogenesis of babesiosis and malaria should lead to additional fundamental insights for both conditions.
Central Nervous System Diseases
Lung Diseases, Parasitic
Severity of Illness Index
Published Version (Please cite this version)10.1016/j.pt.2007.09.005
Publication InfoKrause, Peter J; Daily, Johanna; Telford, Sam R; Vannier, Edouard; Lantos, Paul; & Spielman, Andrew (2007). Shared features in the pathobiology of babesiosis and malaria. Trends Parasitol, 23(12). pp. 605-610. 10.1016/j.pt.2007.09.005. Retrieved from https://hdl.handle.net/10161/13968.
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Associate Professor of Medicine
I am interested in the spatial epidemiology of infectious diseases. My research utilizes geographic information systems (GIS) and geostatistical analyses to understand the spatial and spatiotemporal distribution of diseases, and their relationship with environmental and demographic factors. I currently have active studies evaluating the spatial distribution of numerous domestic and international infectious diseases, including SARS-CoV-2 (COVID-19), cytomegalovirus, influenza, and Lyme disease. A