Lidocaine patch for acute pain management: a meta-analysis of prospective controlled trials.
Abstract
BACKGROUND: Local anesthetic is one of the cornerstones of multimodal analgesia. We
investigated the efficacy of the lidocaine patch for acute pain management. METHODS:
We searched MEDLINE, CINAHL, Scopus, and the Cochrane Controlled Trials Register for
published prospective controlled clinical trials that evaluated the analgesic effect
of the lidocaine patch for acute or postoperative pain management (1966--2014). The
outcomes were postoperative opioid consumption, pain intensity and length of hospital
stay. RESULTS: Five trials comparing the lidocaine patch with control (no treatment/placebo)
for acute or postoperative pain treatment/management were included in this meta-analysis.
Data was analyzed on 251 patients. Between the lidocaine patch group and the control
group, no significant difference was found for all three outcomes (all p > 0.05).
For postoperative opioid consumption, mean difference (MD) was -8.2 mg morphine equivalent
(95% CI -28.68, 12.24). For postoperative pain intensity, MD was -9.1 mm visual analog
scale or equivalent (95% CI -23.31, 5.20). For length of hospital stay, MD was -0.2
days (95% CI -0.80, 0.43). CONCLUSION: Application of a lidocaine patch may not be
an effective adjunct for acute and postoperative pain management, in terms of pain
intensity, opioid consumption and length of hospital stay. LIMITATIONS: The limitations
were a small number of included studies, potential biases from some unblinded studies,
clinical heterogeneity between studies, and incomplete reported data for adjunct analgesics.
Type
Journal articleSubject
Acute painLidocaine patch
Opioid sparing
Postoperative pain
Acute Pain
Analgesics, Opioid
Anesthetics, Local
Humans
Lidocaine
Pain Management
Pain Measurement
Prospective Studies
Transdermal Patch
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https://hdl.handle.net/10161/13998Published Version (Please cite this version)
10.1185/03007995.2014.973484Publication Info
Bai, Yaowu; Miller, Timothy; Tan, Mingjuan; Law, Lawrence Siu-Chun; & Gan, Tong Joo (2015). Lidocaine patch for acute pain management: a meta-analysis of prospective controlled
trials. Curr Med Res Opin, 31(3). pp. 575-581. 10.1185/03007995.2014.973484. Retrieved from https://hdl.handle.net/10161/13998.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Tong Joo Gan
Consulting Professor in the Department of Anesthesiology
My current research interests include postoperative nausea and vomiting (PONV), acute
postoperative pain, clinical pharmacology of anesthetic drugs and resuscitation fluids
as well as database research in postoperative outcomes. Improving Outcome in Surgical
Patients: Nausea and vomiting is regarded as one of the most unpleasant experiences
in postoperative recovery. To date, there is no single antiemetic which can satisfactorily
control PONV. My interests concentrate o
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Timothy Ellis Miller
Professor of Anesthesiology
Clinical and research interests are Enhanced Recovery and Perioperative Medicine;
with particular interests in fluid management, and perioperative optimization of the
high-risk non-cardiac surgery patient.
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