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Country of residence is associated with distinct inflammatory biomarker signatures in HIV-infected patients.

dc.contributor.author Andrade, BB
dc.contributor.author Belaunzaran-Zamudio, PF
dc.contributor.author DerSimonian, R
dc.contributor.author Gu, W
dc.contributor.author Lederman, MM
dc.contributor.author Manion, M
dc.contributor.author Musselwhite, Laura
dc.contributor.author Rupert, A
dc.contributor.author Sanne, I
dc.contributor.author Sereti, I
dc.contributor.author Sierra Madero, JG
dc.coverage.spatial England
dc.date.accessioned 2017-04-14T10:56:59Z
dc.date.available 2017-04-14T10:56:59Z
dc.date.issued 2017-01-01
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/28275455
dc.identifier.issn 2055-6640
dc.identifier.uri https://hdl.handle.net/10161/14015
dc.description.abstract BACKGROUND: Inflammation and coagulation biomarkers are independent predictors of morbidity and mortality in HIV-infected patients. The impact of country of residence on these biomarkers is unknown and was investigated in persons at similar stages of HIV infection. METHODS: Cryopreserved plasma specimens were analysed from 267 ART-naive patients with CD4 cell counts <100 cells/μl from Mexico (n=124) and South Africa (n=143). Biomarkers were compared and dimension reduction analyses were performed to highlight biosignatures according to nationality, gender and tuberculosis co-infection. RESULTS: Mexican patients were significantly different from South Africans with regard to age, gender, CD4 cell count, haemoglobin, presence of AIDS-defining illness and prevalence of active tuberculosis. After adjusting for baseline characteristics, patients from Mexico had higher levels of IFN-γ, IL-8, and CXCL-10 whereas patients from South Africa had higher levels of fibrinogen, LTB4, P-selectin, protein S, and sCD40 ligand. The effect of country on the profile of biomarker expression was stronger than gender differences and tuberculosis co-infection. CONCLUSION: Inflammation and coagulation biomarkers vary significantly by country. Further studies are needed to evaluate how these differences may contribute to HIV pathogenesis and prognosis in diverse populations and how they can be accounted for in studies using biomarkers as surrogate end points.
dc.language eng
dc.relation.ispartof J Virus Erad
dc.subject HIV
dc.subject biomarkers
dc.subject inflammation
dc.subject nationality
dc.title Country of residence is associated with distinct inflammatory biomarker signatures in HIV-infected patients.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/28275455
pubs.begin-page 24
pubs.end-page 33
pubs.issue 1
pubs.organisational-group Duke
pubs.organisational-group Staff
pubs.publication-status Published online
pubs.volume 3


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