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Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research.

dc.contributor.author Phillips, KA
dc.contributor.author Deverka, PA
dc.contributor.author Sox, HC
dc.contributor.author Khoury, MJ
dc.contributor.author Sandy, LG
dc.contributor.author Ginsburg, Geoffrey Steven
dc.contributor.author Tunis, SR
dc.contributor.author Orlando, Lori Ann
dc.contributor.author Douglas, MP
dc.coverage.spatial United States
dc.date.accessioned 2017-05-01T13:27:38Z
dc.date.available 2017-05-01T13:27:38Z
dc.date.issued 2017-04-13
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/28406488
dc.identifier gim201721
dc.identifier.uri http://hdl.handle.net/10161/14222
dc.description.abstract Comparative effectiveness research (CER) in genomic medicine (GM) measures the clinical utility of using genomic information to guide clinical care in comparison to appropriate alternatives. We summarized findings of high-quality systematic reviews that compared the analytic and clinical validity and clinical utility of GM tests. We focused on clinical utility findings to summarize CER-derived evidence about GM and identify evidence gaps and future research needs. We abstracted key elements of study design, GM interventions, results, and study quality ratings from 21 systematic reviews published in 2010 through 2015. More than half (N = 13) of the reviews were of cancer-related tests. All reviews identified potentially important clinical applications of the GM interventions, but most had significant methodological weaknesses that largely precluded any conclusions about clinical utility. Twelve reviews discussed the importance of patient-centered outcomes, although few described evidence about the impact of genomic medicine on these outcomes. In summary, we found a very limited body of evidence about the effect of using genomic tests on health outcomes and many evidence gaps for CER to address.Genet Med advance online publication 13 April 2017Genetics in Medicine (2017); doi:10.1038/gim.2017.21.
dc.language eng
dc.relation.ispartof Genet Med
dc.relation.isversionof 10.1038/gim.2017.21
dc.title Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/28406488
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group Medicine, General Internal Medicine
pubs.organisational-group Nursing
pubs.organisational-group Pathology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group School of Nursing
pubs.publication-status Published online
dc.identifier.eissn 1530-0366


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