Effect of 6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride (Voluven®) on complications after subarachnoid hemorrhage: a retrospective analysis.
Abstract
BACKGROUND: 6% Hydroxyethyl Starch 130/0.4 in 0.9% Sodium Chloride (Voluven®; 6% HES
130/0.4) is a colloid often used for fluid resuscitation in patients with subarachnoid
hemorrhage (SAH), despite a lack of safety data for this use. The purpose of our study
was to evaluate the effect of 6% HES 130/0.4 on major complications associated with
SAH. METHODS: Medical records of all patients presenting between May 2010 and September
2012 with aneurysmal SAH were analyzed. Patients were divided in two groups based
on the administration of 6% HES 130/0.4; HES group (n=57) and Non-HES group (n=72).
The primary outcome included a composite of three major complications associated with
SAH: Delayed Cerebral Ischemia (DCI), Hydrocephalus (HCP) requiring cerebrospinal
fluid (CSF) shunting, and Rebleeding. RESULTS: The study groups were similar with
respect to most characteristics except the incidences of hypertension, ischemic heart
disease, Fisher grade and lowest hemoglobin during stay. The odds of developing the
primary composite outcome was higher in the HES group [OR= 3.1(1.30-7.36), p=0.01].
The patients in the HES group had a significantly longer median duration of hospital
(19 vs 14 days) and Neurointensive Care Unit stay (14 vs 10 days) compared to the
Non HES group. CONCLUSION: We observed increased complications after SAH with 6% HES
130/0.4 (Voluven®) administration. An adequately powered prospective randomized controlled
trial into the safety of 6% HES 130/0.4 in this patient population is warranted.
Type
Journal articleSubject
6% HES 130/0.4Delayed cerebral ischemia
Fluid therapy
Hydrocephalus
Hydroxyethyl starch
Mortality
Rebleeding
Subarachnoid hemorrhage
Voluven
Permalink
https://hdl.handle.net/10161/14237Published Version (Please cite this version)
10.1186/2193-1801-2-314Publication Info
Khan, Shariq A; Adogwa, Owoicho; Gan, Tong J; Null, Ulysses T; Verla, Terence; Gokhale,
Sankalp; ... McDonagh, David L (2013). Effect of 6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride (Voluven®) on complications
after subarachnoid hemorrhage: a retrospective analysis. Springerplus, 2(1). pp. 314. 10.1186/2193-1801-2-314. Retrieved from https://hdl.handle.net/10161/14237.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Tong Joo Gan
Consulting Professor in the Department of Anesthesiology
My current research interests include postoperative nausea and vomiting (PONV), acute
postoperative pain, clinical pharmacology of anesthetic drugs and resuscitation fluids
as well as database research in postoperative outcomes. Improving Outcome in Surgical
Patients: Nausea and vomiting is regarded as one of the most unpleasant experiences
in postoperative recovery. To date, there is no single antiemetic which can satisfactorily
control PONV. My interests concentrate o
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special
research interest in translational and clinical research aspects of intracerebral
hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical
care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral
hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University.
After optimization of the model, I h
David Lawrence McDonagh
Adjunct Associate Professor in the Department of Anesthesiology
My research interests are in two main areas: 1. Neurologic and cognitive outcomes
after major noncardiac surgery. 2. Neurocritical Care.
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Ali Reza Zomorodi
Professor of Neurosurgery
Alphabetical list of authors with Scholars@Duke profiles.

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info