Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.
Abstract
BACKGROUND: Intraoperative intravascular volume expansion with hydroxyethyl starch-based
colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage.
Evidence for this association is limited. Associations between resuscitation with
hydroxyethyl starch and risk of repeat craniotomy for hematoma evacuation were examined.
METHODS: Using a retrospective cohort of neurosurgical patients at Duke University
Medical Center between March 2005 and March 2012, patient characteristics were compared
between those who developed post-craniotomy hemorrhage and those who did not. RESULTS:
A total of 4,109 craniotomy procedures were analyzed with 61 patients having repeat
craniotomy for post-operative hemorrhage (1.5%). The rate of reoperation in the group
receiving 6% High Molecular Weight Hydroxyethyl Starch (Hextend(®)) was 2.6 vs. 1.3%
for patients that did not receive hetastarch (P = 0.13). The reoperation rate for
those receiving 6% hydroxyethyl Starch 130/0.4 (Voluven(®)) was 1.4 vs. 1.6% in patients
not receiving Voluven (P = 0.85). CONCLUSIONS: In this retrospective cohort, intra-operative
hydroxyethyl starch was not associated with an increased risk of post-craniotomy hemorrhage.
Type
Journal articlePermalink
https://hdl.handle.net/10161/14243Published Version (Please cite this version)
10.1186/s40064-015-1126-0Publication Info
Feix, James A; Peery, C Andrew; Gan, Tong J; Warner, David S; James, Michael L; Zomorodi,
Ali; & McDonagh, David L (2015). Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.
Springerplus, 4. pp. 350. 10.1186/s40064-015-1126-0. Retrieved from https://hdl.handle.net/10161/14243.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Michael Lucas James
Professor of Anesthesiology
With a clinical background in neuroanesthesia and neurointensive care, I have a special
interest in translational research in intracerebral hemorrhage and traumatic brain
injury. I am fortunate to be part of a unique team of highly motivated and productive
individuals who allow me to propel ideas from bench to bedside and the ability to
reverse translate ideas from the bedside back to the bench.
David Lawrence McDonagh
Adjunct Associate Professor in the Department of Anesthesiology
My research interests are in two main areas: 1. Neurologic and cognitive outcomes
after major noncardiac surgery. 2. Neurocritical Care.
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Charles Andrew Peery
Assistant Professor of Anesthesiology
David Samuel Warner
Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine
Humans may sustain a variety of forms of acute central nervous system injury including
ischemia, trauma, vasospasm, and perinatal hypoxemia. The Multidisciplinary Neuroprotection
Laboratories is dedicated to examining the pathophysiology of acute brain and spinal
cord injury with particular reference to disease states managed in the perioperative
or neurointensive care environments. Rodent recovery models of cerebral ischemia,
traumatic brain injury, cardiopulmonary bypass, subarachnoid he
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Ali Reza Zomorodi
Professor of Neurosurgery
Alphabetical list of authors with Scholars@Duke profiles.

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info