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Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.

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Date
2015
Authors
Feix, James A
Peery, C Andrew
Gan, Tong J
Warner, David S
James, Michael L
Zomorodi, Ali
McDonagh, David L
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Abstract
BACKGROUND: Intraoperative intravascular volume expansion with hydroxyethyl starch-based colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage. Evidence for this association is limited. Associations between resuscitation with hydroxyethyl starch and risk of repeat craniotomy for hematoma evacuation were examined. METHODS: Using a retrospective cohort of neurosurgical patients at Duke University Medical Center between March 2005 and March 2012, patient characteristics were compared between those who developed post-craniotomy hemorrhage and those who did not. RESULTS: A total of 4,109 craniotomy procedures were analyzed with 61 patients having repeat craniotomy for post-operative hemorrhage (1.5%). The rate of reoperation in the group receiving 6% High Molecular Weight Hydroxyethyl Starch (Hextend(®)) was 2.6 vs. 1.3% for patients that did not receive hetastarch (P = 0.13). The reoperation rate for those receiving 6% hydroxyethyl Starch 130/0.4 (Voluven(®)) was 1.4 vs. 1.6% in patients not receiving Voluven (P = 0.85). CONCLUSIONS: In this retrospective cohort, intra-operative hydroxyethyl starch was not associated with an increased risk of post-craniotomy hemorrhage.
Type
Journal article
Subject
Colloid
Craniotomy
Hemorrhage
Hydroxyethyl starch
Neuroanesthesia
Neurosurgery
Permalink
https://hdl.handle.net/10161/14243
Published Version (Please cite this version)
10.1186/s40064-015-1126-0
Publication Info
Feix, James A; Peery, C Andrew; Gan, Tong J; Warner, David S; James, Michael L; Zomorodi, Ali; & McDonagh, David L (2015). Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage. Springerplus, 4. pp. 350. 10.1186/s40064-015-1126-0. Retrieved from https://hdl.handle.net/10161/14243.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

James

Michael Lucas James

Professor of Anesthesiology
With a clinical background in neuroanesthesia and neurointensive care, I have a special interest in translational research in intracerebral hemorrhage and traumatic brain injury. I am fortunate to be part of a unique team of highly motivated and productive individuals who allow me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench.
McDonagh

David Lawrence McDonagh

Adjunct Associate Professor in the Department of Anesthesiology
My research interests are in two main areas: 1. Neurologic and cognitive outcomes after major noncardiac surgery. 2. Neurocritical Care.
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Peery

Charles Andrew Peery

Assistant Professor of Anesthesiology
Warner

David Samuel Warner

Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine
Humans may sustain a variety of forms of acute central nervous system injury including ischemia, trauma, vasospasm, and perinatal hypoxemia. The Multidisciplinary Neuroprotection Laboratories is dedicated to examining the pathophysiology of acute brain and spinal cord injury with particular reference to disease states managed in the perioperative or neurointensive care environments. Rodent recovery models of cerebral ischemia, traumatic brain injury, cardiopulmonary bypass, subarachnoid he
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Zomorodi

Ali Reza Zomorodi

Professor of Neurosurgery
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