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Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.

dc.contributor.author Feix, James A
dc.contributor.author Peery, C Andrew
dc.contributor.author Gan, Tong J
dc.contributor.author Warner, David S
dc.contributor.author James, Michael L
dc.contributor.author Zomorodi, Ali
dc.contributor.author McDonagh, David L
dc.coverage.spatial Switzerland
dc.date.accessioned 2017-05-01T17:23:21Z
dc.date.available 2017-05-01T17:23:21Z
dc.date.issued 2015
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/26191477
dc.identifier 1126
dc.identifier.uri https://hdl.handle.net/10161/14243
dc.description.abstract BACKGROUND: Intraoperative intravascular volume expansion with hydroxyethyl starch-based colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage. Evidence for this association is limited. Associations between resuscitation with hydroxyethyl starch and risk of repeat craniotomy for hematoma evacuation were examined. METHODS: Using a retrospective cohort of neurosurgical patients at Duke University Medical Center between March 2005 and March 2012, patient characteristics were compared between those who developed post-craniotomy hemorrhage and those who did not. RESULTS: A total of 4,109 craniotomy procedures were analyzed with 61 patients having repeat craniotomy for post-operative hemorrhage (1.5%). The rate of reoperation in the group receiving 6% High Molecular Weight Hydroxyethyl Starch (Hextend(®)) was 2.6 vs. 1.3% for patients that did not receive hetastarch (P = 0.13). The reoperation rate for those receiving 6% hydroxyethyl Starch 130/0.4 (Voluven(®)) was 1.4 vs. 1.6% in patients not receiving Voluven (P = 0.85). CONCLUSIONS: In this retrospective cohort, intra-operative hydroxyethyl starch was not associated with an increased risk of post-craniotomy hemorrhage.
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof Springerplus
dc.relation.isversionof 10.1186/s40064-015-1126-0
dc.subject Colloid
dc.subject Craniotomy
dc.subject Hemorrhage
dc.subject Hydroxyethyl starch
dc.subject Neuroanesthesia
dc.subject Neurosurgery
dc.title Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.
dc.type Journal article
duke.contributor.id Peery, C Andrew|0262582
duke.contributor.id Warner, David S|0116342
duke.contributor.id James, Michael L|0225034
duke.contributor.id Zomorodi, Ali|0051103
duke.contributor.id McDonagh, David L|0225067
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/26191477
pubs.begin-page 350
pubs.organisational-group Anesthesiology
pubs.organisational-group Anesthesiology, Neuroanesthesia
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Neurology
pubs.organisational-group Neurology, Neurocritical Care
pubs.organisational-group Neurosurgery
pubs.organisational-group School of Medicine
pubs.organisational-group Surgery
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published online
pubs.volume 4
duke.contributor.orcid James, Michael L|0000-0002-8715-5210


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