Vaginal Self-Sampling for Human Papillomavirus Infection as a Primary Cervical Cancer Screening Tool in a Haitian Population.
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BACKGROUND: Human papillomavirus (HPV) testing as primary cervical cancer screening has not been studied in Caribbean women. We tested vaginal self-collection versus physician cervical sampling in a population of Haitian women. METHODS: Participants were screened for high-risk HPV with self-performed vaginal and clinician-collected cervical samples using Hybrid Capture 2 assays (Qiagen, Gaithersburg, MD). Women positive by either method then underwent colposcopy with biopsy of all visible lesions. Sensitivity and positive predictive value were calculated for each sample method compared with biopsy results, with κ statistics performed for agreement. McNemar tests were performed for differences in sensitivity at ≥cervical intraepithelial neoplasia (CIN)-I and ≥CIN-II. RESULTS: Of 1845 women screened, 446 (24.3%) were HPV positive by either method, including 105 (5.7%) only by vaginal swab and 53 (2.9%) only by cervical swab. Vaginal and cervical samples were 91.4% concordant (κ = 0.73 [95% confidence interval, 0.69-0.77], P < 0.001). Overall, 133 HPV-positive women (29.9%) had CIN-I, whereas 32 (7.2%) had ≥CIN-II. The sensitivity of vaginal swabs was similar to cervical swabs for detecting ≥CIN-I (89.1% vs. 87.9%, respectively; P = 0.75) lesions and ≥CIN-II disease (87.5% vs. 96.9%, P = 0.18). Eighteen of 19 cases of CIN-III and invasive cancer were found by both methods. CONCLUSIONS: Human papillomavirus screening via self-collected vaginal swabs or physician-collected cervical swabs are feasible options in this Haitian population. The agreement between cervical and vaginal samples was high, suggesting that vaginal sample-only algorithms for screening could be effective for improving screening rates in this underscreened population.
Cervical Intraepithelial Neoplasia
Early Detection of Cancer
Predictive Value of Tests
Sensitivity and Specificity
Uterine Cervical Neoplasms
Published Version (Please cite this version)10.1097/OLQ.0000000000000345
Publication InfoBeauvais, HJ; Boggan, Joel; Chakhtoura, N; Henderson, G; McCarthy, Schatzi H; Smith, JS; & Walmer, DK (2015). Vaginal Self-Sampling for Human Papillomavirus Infection as a Primary Cervical Cancer Screening Tool in a Haitian Population. Sex Transm Dis, 42(11). pp. 655-659. 10.1097/OLQ.0000000000000345. Retrieved from http://hdl.handle.net/10161/14596.
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Assistant Professor of Medicine
My current QI and research projects include work on readmissions, hospital-acquired infections, clinical documentation improvement, and optimization of chronic kidney disease and cardiovascular disease management and referral patterns. I also oversee QI education and projects for the Internal Medicine Residency Program as the Associate Program Director for Quality Improvement and Patient Safety. My other teaching roles include housestaff and student clinical teaching and