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    DNA methylation age is associated with mortality in a longitudinal Danish twin study.

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    Date
    2016-02
    Authors
    Aviv, A
    Christensen, Kaare
    Christiansen, L
    Lenart, A
    McGue, M
    Tan, Q
    Vaupel, James Walton
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    Abstract
    An epigenetic profile defining the DNA methylation age (DNAm age) of an individual has been suggested to be a biomarker of aging, and thus possibly providing a tool for assessment of health and mortality. In this study, we estimated the DNAm age of 378 Danish twins, age 30-82 years, and furthermore included a 10-year longitudinal study of the 86 oldest-old twins (mean age of 86.1 at follow-up), which subsequently were followed for mortality for 8 years. We found that the DNAm age is highly correlated with chronological age across all age groups (r = 0.97), but that the rate of change of DNAm age decreases with age. The results may in part be explained by selective mortality of those with a high DNAm age. This hypothesis was supported by a classical survival analysis showing a 35% (4-77%) increased mortality risk for each 5-year increase in the DNAm age vs. chronological age. Furthermore, the intrapair twin analysis revealed a more-than-double mortality risk for the DNAm oldest twin compared to the co-twin and a 'dose-response pattern' with the odds of dying first increasing 3.2 (1.05-10.1) times per 5-year DNAm age difference within twin pairs, thus showing a stronger association of DNAm age with mortality in the oldest-old when controlling for familial factors. In conclusion, our results support that DNAm age qualifies as a biomarker of aging.
    Type
    Journal article
    Subject
    DNA methylation
    biological age
    biomarker
    epigenetic clock
    mortality
    twins
    Adult
    Aged
    Aged, 80 and over
    Aging
    DNA Methylation
    Denmark
    Epigenesis, Genetic
    Female
    Humans
    Longitudinal Studies
    Male
    Middle Aged
    Molecular Sequence Data
    Mortality
    Permalink
    http://hdl.handle.net/10161/14649
    Published Version (Please cite this version)
    10.1111/acel.12421
    Publication Info
    Aviv, A; Christensen, Kaare; Christiansen, L; Lenart, A; McGue, M; Tan, Q; & Vaupel, James Walton (2016). DNA methylation age is associated with mortality in a longitudinal Danish twin study. Aging Cell, 15(1). pp. 149-154. 10.1111/acel.12421. Retrieved from http://hdl.handle.net/10161/14649.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    Vaupel

    James Walton Vaupel

    Research Professor in the Sanford School of Public Policy
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