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    Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.

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    Date
    2016-06
    Authors
    Bolund, L
    Chen, H
    Feng, L
    Gottschalk, William Kirby
    Gregory, Simon Gray
    Gu, J
    Hauser, Elizabeth Rebecca
    Land, Kenneth C
    Li, J
    Li, Y
    Liu, X
    Lu, Jianfeng
    Lutz, Michael William
    Min, J
    Ming, Q
    Ni, T
    Nie, C
    Ruan, R
    Tan, Q
    Tao, W
    Tian, X-L
    Vaupel, James Walton
    Willcox, BJ
    Willcox, DC
    Yang, Huanming
    Yang, Z
    Yashin, Anatoli I
    Zeng, Y
    Zhang, F
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    (29 total)
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    Abstract
    On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that interactions between carrying FOXO1A-209 genotypes and tea drinking are significantly associated with lower risk of mortality at advanced ages. Such a significant association is replicated in two independent Han Chinese CLHLS cohorts (p = 0.028-0.048 in the discovery and replication cohorts, and p = 0.003-0.016 in the combined dataset). We found the associations between tea drinking and reduced mortality are much stronger among carriers of the FOXO1A-209 genotype compared to non-carriers, and drinking tea is associated with a reversal of the negative effects of carrying FOXO1A-209 minor alleles, that is, from a substantially increased mortality risk to substantially reduced mortality risk at advanced ages. The impacts are considerably stronger among those who carry two copies of the FOXO1A minor allele than those who carry one copy. On the basis of previously reported experiments on human cell models concerning FOXO1A-by-tea-compounds interactions, we speculate that results in the present study indicate that tea drinking may inhibit FOXO1A-209 gene expression and its biological functions, which reduces the negative impacts of FOXO1A-209 gene on longevity (as reported in the literature) and offers protection against mortality risk at oldest-old ages. Our empirical findings imply that the health outcomes of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles, and the research on the effects of nutrigenomics interactions could potentially be useful for rejuvenation therapies in the clinic or associated healthy aging intervention programs.
    Type
    Journal article
    Subject
    Age Factors
    Aged, 80 and over
    Aging
    Cause of Death
    China
    Female
    Forkhead Box Protein O1
    Gene Frequency
    Gene-Environment Interaction
    Genotype
    Heterozygote
    Homozygote
    Humans
    Male
    Phenotype
    Protective Factors
    Risk Assessment
    Risk Factors
    Survival Analysis
    Permalink
    https://hdl.handle.net/10161/14659
    Published Version (Please cite this version)
    10.1089/rej.2015.1737
    Publication Info
    Bolund, L; Chen, H; Feng, L; Gottschalk, William Kirby; Gregory, Simon Gray; Gu, J; ... Zhang, F (2016). Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages. Rejuvenation Res, 19(3). pp. 195-203. 10.1089/rej.2015.1737. Retrieved from https://hdl.handle.net/10161/14659.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    Gottschalk

    William Kirby Gottschalk

    Assistant Professor of Neurology
    Gregory

    Simon Gray Gregory

    Professor in Neurology
    My principal area of research involves elucidating the molecular mechanisms underlying multi-factorial diseases. My lab is primarily interested identifying the complex genetic factors that give rise to multiple sclerosis, autism and cardiovascular disease. We are using targeted approaches to identify differential methylation of the oxytocin receptor gene (OXTR) in individuals with autism, and applying these data to an NICHD funded ACE award, SOARS-B, to assess long term use of oxytocin nasal spr

    Elizabeth Rebecca Hauser

    Professor of Biostatistics and Bioinformatics
    My research interests are focused on developing and applying statistical methods to search for genes causing common human diseases. Recent work has been in the development of statistical methods for genetic studies and in identifying optimal study designs for genetic studies of complex traits. As application of these methods to specific diseases has progressed it has become apparent that etiologic and genetic heterogeneity is a major stumbling block in the research for genes for common diseases.
    Land

    Kenneth C. Land

    John Franklin Crowell Professor Emeritus of Sociology
    I received my Ph.D. in sociology and mathematics from the University of Texas at Austin in 1969. After a year of postdoctoral study in mathematical statistics at Columbia University in New York City, I taught there and was a member of the staff of the Russell Sage Foundation for three years. I then was successively a member of the faculties of the University of Illinois at Urbana Champaign and the University of Texas at Austin before joining the Duke Sociology Department as Chairman in
    Lu

    Jianfeng Lu

    Associate Professor of Mathematics
    Jianfeng Lu is an applied mathematician interested in mathematical analysis and algorithm development for problems from computational physics, theoretical chemistry, materials science and other related fields.More specifically, his current research focuses include:Electronic structure and many body problems; quantum molecular dynamics; multiscale modeling and analysis; rare events and sampling techniques.
    Lutz

    Michael William Lutz

    Assistant Professor of Neurology
    Developing and using computational biology methods to understand the genetic basis of disease with a focus on Alzheimer’s Disease.   Recent work has focused on identification and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s disease with Lewy bodies.
    Vaupel

    James Walton Vaupel

    Research Professor in the Sanford School of Public Policy
    Yashin

    Anatoli I. Yashin

    Research Professor in the Social Science Research Institute
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