Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.
Abstract
On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity
Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that
interactions between carrying FOXO1A-209 genotypes and tea drinking are significantly
associated with lower risk of mortality at advanced ages. Such a significant association
is replicated in two independent Han Chinese CLHLS cohorts (p = 0.028-0.048 in the
discovery and replication cohorts, and p = 0.003-0.016 in the combined dataset). We
found the associations between tea drinking and reduced mortality are much stronger
among carriers of the FOXO1A-209 genotype compared to non-carriers, and drinking tea
is associated with a reversal of the negative effects of carrying FOXO1A-209 minor
alleles, that is, from a substantially increased mortality risk to substantially reduced
mortality risk at advanced ages. The impacts are considerably stronger among those
who carry two copies of the FOXO1A minor allele than those who carry one copy. On
the basis of previously reported experiments on human cell models concerning FOXO1A-by-tea-compounds
interactions, we speculate that results in the present study indicate that tea drinking
may inhibit FOXO1A-209 gene expression and its biological functions, which reduces
the negative impacts of FOXO1A-209 gene on longevity (as reported in the literature)
and offers protection against mortality risk at oldest-old ages. Our empirical findings
imply that the health outcomes of particular nutritional interventions, including
tea drinking, may, in part, depend upon individual genetic profiles, and the research
on the effects of nutrigenomics interactions could potentially be useful for rejuvenation
therapies in the clinic or associated healthy aging intervention programs.
Type
Journal articleSubject
Age FactorsAged, 80 and over
Aging
Cause of Death
China
Female
Forkhead Box Protein O1
Gene Frequency
Gene-Environment Interaction
Genotype
Heterozygote
Homozygote
Humans
Male
Phenotype
Protective Factors
Risk Assessment
Risk Factors
Survival Analysis
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https://hdl.handle.net/10161/14659Published Version (Please cite this version)
10.1089/rej.2015.1737Publication Info
Bolund, L; Chen, H; Feng, L; Gottschalk, William Kirby; Gregory, Simon Gray; Gu, J;
... Zhang, F (2016). Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated
with Reduced Mortality at Advanced Ages. Rejuvenation Res, 19(3). pp. 195-203. 10.1089/rej.2015.1737. Retrieved from https://hdl.handle.net/10161/14659.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
William Kirby Gottschalk
Assistant Professor of Neurology
Simon Gray Gregory
Professor in Neurology
My principal area of research involves elucidating the molecular mechanisms underlying
multi-factorial diseases. My lab is primarily interested identifying the complex genetic
factors that give rise to multiple sclerosis, autism and cardiovascular disease. We
are using targeted approaches to identify differential methylation of the oxytocin
receptor gene (OXTR) in individuals with autism, and applying these data to an NICHD
funded ACE award, SOARS-B, to assess long term use of oxytocin nasal spr
Elizabeth Rebecca Hauser
Professor of Biostatistics and Bioinformatics
My research interests are focused on developing and applying statistical methods to
search for genes causing common human diseases. Recent work has been in the development
of statistical methods for genetic studies and in identifying optimal study designs
for genetic studies of complex traits. As application of these methods to specific
diseases has progressed it has become apparent that etiologic and genetic heterogeneity
is a major stumbling block in the research for genes for common diseases.
Kenneth C. Land
John Franklin Crowell Professor Emeritus of Sociology
I received my Ph.D. in sociology and mathematics from
the University of Texas at Austin in 1969. After a year of
postdoctoral study in mathematical statistics at
Columbia University in New York City, I taught there
and was a member of the staff of the Russell Sage
Foundation for three years. I then was successively a
member of the faculties of the University of Illinois at
Urbana Champaign and the University of Texas at Austin
before joining the Duke Sociology Department as
Chairman in
Jianfeng Lu
Associate Professor of Mathematics
Jianfeng Lu is an applied mathematician interested in mathematical analysis and algorithm
development for problems from computational physics, theoretical chemistry, materials
science and other related fields.More specifically, his current research focuses include:Electronic
structure and many body problems; quantum molecular dynamics; multiscale modeling
and analysis; rare events and sampling techniques.
Michael William Lutz
Assistant Professor of Neurology
Developing and using computational biology methods to understand the genetic basis
of disease with a focus on Alzheimer’s Disease. Recent work has focused on identification
and validation of clinically-relevant biomarkers for Alzheimer’s disease and Alzheimer’s
disease with Lewy bodies.
James Walton Vaupel
Research Professor in the Sanford School of Public Policy
Anatoli I. Yashin
Research Professor in the Social Science Research Institute
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