GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.
Abstract
Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+
demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292
and tea drinking at around age 60 or at present time were significantly associated
with lower risk of cognitive disability at advanced ages. Associations between tea
drinking and reduced cognitive disability were much stronger among carriers of the
genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it
was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking
at around age 60, and at present time. Based on prior findings from animal and human
cell models, we postulate that intake of tea compounds may activate FOXO gene expression,
which in turn may positively affect cognitive function in the oldest old population.
Our empirical findings imply that the health benefits of particular nutritional interventions,
including tea drinking, may, in part, depend upon individual genetic profiles.
Type
Journal articleSubject
Cognitive disabilityFOXO genotypes
GxE interactions
Oldest old.
Tea drinking
Aged, 80 and over
Aging
Alleles
Asian Continental Ancestry Group
China
Cognition
Cognition Disorders
Drinking Behavior
Evidence-Based Medicine
Female
Forkhead Box Protein O1
Forkhead Box Protein O3
Forkhead Transcription Factors
Gene Expression
Genotype
Humans
Longitudinal Studies
Male
Phenotype
Risk Factors
Surveys and Questionnaires
Tea
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https://hdl.handle.net/10161/14682Published Version (Please cite this version)
10.1093/gerona/glu060Publication Info
Zeng, Yi; Chen, Huashuai; Ni, Ting; Ruan, Rongping; Feng, Lei; Nie, Chao; ... Vaupel,
James W (2015). GxE interactions between FOXO genotypes and drinking tea are significantly associated
with prevention of cognitive decline in advanced age in China. J Gerontol A Biol Sci Med Sci, 70(4). pp. 426-433. 10.1093/gerona/glu060. Retrieved from https://hdl.handle.net/10161/14682.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Elizabeth Rebecca Hauser
Professor of Biostatistics and Bioinformatics
My research interests are focused on developing and applying statistical methods to
search for genes causing common human diseases. Recent work has been in the development
of statistical methods for genetic studies and in identifying optimal study designs
for genetic studies of complex traits. As application of these methods to specific
diseases has progressed it has become apparent that etiologic and genetic heterogeneity
is a major stumbling block in the research for genes for common diseases.
Kenneth C. Land
John Franklin Crowell Distinguished Professor Emeritus of Sociology
I received my Ph.D. in sociology and mathematics from
the University of Texas at Austin in 1969. After a year of
postdoctoral study in mathematical statistics at
Columbia University in New York City, I taught there
and was a member of the staff of the Russell Sage
Foundation for three years. I then was successively a
member of the faculties of the University of Illinois at
Urbana Champaign and the University of Texas at Austin
before joining the Duke Sociology Department as
Chairman in
James Walton Vaupel
Research Professor in the Sanford School of Public Policy
Anatoli I. Yashin
Research Professor in the Social Science Research Institute
Yi Zeng
Professor in Medicine
(1) Socioeconomic, behavior, environmental and genetic determinants of healthy aging
and healthy longevity; (2) Factors related to elderly disability and mental health;
(3) Methods of family households and elderly living arrangements forecasting/analysis
and their applications in health services and socioeconomic planning, and market studies;
(4) Policy analysis in population aging, social welfare, retirement, and fertility
transitions.
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