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GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.

dc.contributor.author Bolund, L
dc.contributor.author Chen, H
dc.contributor.author Cheng, L
dc.contributor.author Feng, L
dc.contributor.author Gu, J
dc.contributor.author Hauser, Elizabeth Rebecca
dc.contributor.author Land, Kenneth C
dc.contributor.author Li, Y
dc.contributor.author Ni, T
dc.contributor.author Nie, C
dc.contributor.author Ruan, R
dc.contributor.author Tan, Q
dc.contributor.author Tao, W
dc.contributor.author Tian, X-L
dc.contributor.author Vaupel, James Walton
dc.contributor.author Willcox, BJ
dc.contributor.author Willcox, DC
dc.contributor.author Yang, Haizhao
dc.contributor.author Yang, Z
dc.contributor.author Yashin, Anatoli I
dc.contributor.author Zeng, Y
dc.coverage.spatial United States
dc.date.accessioned 2017-06-01T19:18:18Z
dc.date.available 2017-06-01T19:18:18Z
dc.date.issued 2015-04
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/24895270
dc.identifier glu060
dc.identifier.uri https://hdl.handle.net/10161/14682
dc.description.abstract Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles.
dc.language eng
dc.relation.ispartof J Gerontol A Biol Sci Med Sci
dc.relation.isversionof 10.1093/gerona/glu060
dc.subject Cognitive disability
dc.subject FOXO genotypes
dc.subject GxE interactions
dc.subject Oldest old.
dc.subject Tea drinking
dc.subject Aged, 80 and over
dc.subject Aging
dc.subject Alleles
dc.subject Asian Continental Ancestry Group
dc.subject China
dc.subject Cognition
dc.subject Cognition Disorders
dc.subject Drinking Behavior
dc.subject Evidence-Based Medicine
dc.subject Female
dc.subject Forkhead Box Protein O1
dc.subject Forkhead Box Protein O3
dc.subject Forkhead Transcription Factors
dc.subject Gene Expression
dc.subject Genotype
dc.subject Humans
dc.subject Longitudinal Studies
dc.subject Male
dc.subject Phenotype
dc.subject Risk Factors
dc.subject Surveys and Questionnaires
dc.subject Tea
dc.title GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/24895270
pubs.begin-page 426
pubs.end-page 433
pubs.issue 4
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biostatistics & Bioinformatics
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Center for the Study of Aging and Human Development
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Geriatrics
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group Sociology
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 70
dc.identifier.eissn 1758-535X


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