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Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.

dc.contributor.author Alam, S Munir
dc.contributor.author Bailer, RT
dc.contributor.author Buzby, AP
dc.contributor.author Denny, Thomas Norton
dc.contributor.author Ferrari, Guido
dc.contributor.author Fischer, W
dc.contributor.author Foulds, KE
dc.contributor.author Gottardo, R
dc.contributor.author Gu, W
dc.contributor.author Keele, BF
dc.contributor.author Korber, Bette T
dc.contributor.author Koup, Richard A
dc.contributor.author LaBranche, Celia Crane
dc.contributor.author Letvin, NL
dc.contributor.author Louder, MK
dc.contributor.author Mach, LV
dc.contributor.author Mascola, JR
dc.contributor.author Mason, RD
dc.contributor.author Montefiori, David Charles
dc.contributor.author Nabel, GJ
dc.contributor.author Nason, MC
dc.contributor.author Rao, SS
dc.contributor.author Roederer, M
dc.contributor.author Schmidt, SD
dc.contributor.author Seaton, Kelly
dc.contributor.author Seder, RA
dc.contributor.author Shen, L
dc.contributor.author Todd, JPM
dc.contributor.author Tomaras, Georgia Doris
dc.contributor.author Ward, B
dc.contributor.author Welles, HC
dc.contributor.author Yang, Z-Y
dc.coverage.spatial England
dc.date.accessioned 2017-06-01T20:14:42Z
dc.date.available 2017-06-01T20:14:42Z
dc.date.issued 2014-01-23
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/24352234
dc.identifier nature12893
dc.identifier.uri https://hdl.handle.net/10161/14719
dc.description.abstract A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a nonhuman primate challenge model with simian immunodeficiency virus (SIV). We show that antibodies to the SIV envelope are necessary and sufficient to prevent infection. Moreover, sequencing of viruses from breakthrough infections revealed selective pressure against neutralization-sensitive viruses; we identified a two-amino-acid signature that alters antigenicity and confers neutralization resistance. A similar signature confers resistance of human immunodeficiency virus (HIV)-1 to neutralization by monoclonal antibodies against variable regions 1 and 2 (V1V2), suggesting that SIV and HIV share a fundamental mechanism of immune escape from vaccine-elicited or naturally elicited antibodies. These analyses provide insight into the limited efficacy seen in HIV vaccine trials.
dc.language eng
dc.relation.ispartof Nature
dc.relation.isversionof 10.1038/nature12893
dc.subject AIDS Vaccines
dc.subject Amino Acid Sequence
dc.subject Animals
dc.subject Antibodies, Neutralizing
dc.subject Disease Susceptibility
dc.subject Female
dc.subject Founder Effect
dc.subject HIV Antibodies
dc.subject HIV Infections
dc.subject HIV-1
dc.subject Humans
dc.subject Immune Evasion
dc.subject Macaca mulatta
dc.subject Male
dc.subject Molecular Sequence Data
dc.subject Phylogeny
dc.subject Risk
dc.subject SAIDS Vaccines
dc.subject Simian Acquired Immunodeficiency Syndrome
dc.subject Simian Immunodeficiency Virus
dc.subject env Gene Products, Human Immunodeficiency Virus
dc.title Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/24352234
pubs.begin-page 502
pubs.end-page 508
pubs.issue 7484
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Human Vaccine Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Duke Human Vaccine Institute
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group Surgery
pubs.organisational-group Surgery, Surgical Sciences
pubs.publication-status Published
pubs.volume 505
dc.identifier.eissn 1476-4687


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