Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.
Abstract
Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs),
rarely transmit SIV via breast-feeding. In order to examine the genetic diversity
of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic
analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity
milk virus populations were compartmentalized from that in plasma. However, this compartmentalization
was transient, as the milk virus lineages did not persist longitudinally.
Type
Journal articleSubject
AnimalsCercopithecus aethiops
Cluster Analysis
Female
Gene Products, env
Genetic Variation
Milk, Human
Phylogeny
Plasma
Sequence Analysis, DNA
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
Permalink
https://hdl.handle.net/10161/14723Published Version (Please cite this version)
10.1128/JVI.01643-13Publication Info
(2013). Transient compartmentalization of simian immunodeficiency virus variants in the breast
milk of african green monkeys. J Virol, 87(20). pp. 11292-11299. 10.1128/JVI.01643-13. Retrieved from https://hdl.handle.net/10161/14723.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Thomas Norton Denny
Professor in Medicine
Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine
Institute (DHVI), Associate Dean for Duke Research and Discovery @RTP, and a Professor
of Medicine in the Department of Medicine at Duke University Medical Center. He is
also an Affiliate Member of the Duke Global Health Institute. Previously, he served
on the Health Sector Advisory Council of the Duke University Fuquay School of Business.
Prior to joining Duke, he was an Associate Professor of Pathology, Labo
Sallie Robey Permar
Adjunct Professor in the Department of Pathology
Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission
of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS
to characterize the virus-specific immune responses and virus evolution in breast
milk and develop a maternal vaccine regimen for protection against breast milk transmission
of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific
immune responses and virus evolution in vertically-transmitting an
Allen G Rodrigo
Adjunct Professor of Biology
My research focuses on evolutionary bioinformatics and computatioanl biology. In particular,
I am interested in the development of novel methods to study the evolution of genes,
genomes, organisms and species.
Alphabetical list of authors with Scholars@Duke profiles.
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info