Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.
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Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.
Gene Products, env
Sequence Analysis, DNA
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
Published Version (Please cite this version)10.1128/JVI.01643-13
Publication InfoHo, Carrie; Wu, Steven; Amos, Joshua D; Colvin, Lisa; Smith, Shannon D; Wilks, Andrew B; ... Permar, Sallie R (2013). Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys. J Virol, 87(20). pp. 11292-11299. 10.1128/JVI.01643-13. Retrieved from https://hdl.handle.net/10161/14723.
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Professor in Medicine
Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine Institute (DHVI) and the Center for HIV/AIDS Vaccine Immunology (CHAVI), and a Professor of Medicine in the Department of Medicine at Duke University Medical Center. He is also an Affiliate Member of the Duke Global Health Institute. He has recently been appointed to the Duke University Fuqua School of Business Health Sector Advisory Council. Previously, he was an Associate Professor of Pathology, Laboratory M
Wilburt C. Davison Distinguished Professor
Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting an
Adjunct Professor of Biology
My research focuses on evolutionary bioinformatics and computatioanl biology. In particular, I am interested in the development of novel methods to study the evolution of genes, genomes, organisms and species.
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