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Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys. Ho, Carrie Wu, Steven Amos, Joshua D Colvin, Lisa Smith, Shannon D Wilks, Andrew B Demarco, C Todd Brinkley, Christie Denny, Thomas N Schmitz, Joern E Rodrigo, Allen G Permar, Sallie R
dc.coverage.spatial United States 2017-06-01T20:18:45Z 2017-06-01T20:18:45Z 2013-10
dc.identifier JVI.01643-13
dc.description.abstract Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.
dc.language eng
dc.publisher American Society for Microbiology
dc.relation.ispartof J Virol
dc.relation.isversionof 10.1128/JVI.01643-13
dc.subject Animals
dc.subject Cercopithecus aethiops
dc.subject Cluster Analysis
dc.subject Female
dc.subject Gene Products, env
dc.subject Genetic Variation
dc.subject Milk, Human
dc.subject Phylogeny
dc.subject Plasma
dc.subject Sequence Analysis, DNA
dc.subject Simian Acquired Immunodeficiency Syndrome
dc.subject Simian Immunodeficiency Virus
dc.title Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.
dc.type Journal article Denny, Thomas N|0400543 Rodrigo, Allen G|0523698 Permar, Sallie R|0554303
pubs.begin-page 11292
pubs.end-page 11299
pubs.issue 20
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biology
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Human Vaccine Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Duke Human Vaccine Institute
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Pediatrics
pubs.organisational-group Pediatrics, Infectious Diseases
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 87
dc.identifier.eissn 1098-5514

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