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Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys.

dc.contributor.author Amos, JD
dc.contributor.author Beck, K
dc.contributor.author Colvin, L
dc.contributor.author Demarco, C Todd
dc.contributor.author Denny, Thomas Norton
dc.contributor.author Fouda, Genevieve
dc.contributor.author Ho, C
dc.contributor.author Hodge, TL
dc.contributor.author LaBranche, Celia Crane
dc.contributor.author Liao, Hua-Xin
dc.contributor.author Mahlokozera, T
dc.contributor.author Montefiori, David Charles
dc.contributor.author Moody, M Anthony
dc.contributor.author Overman, RG
dc.contributor.author Permar, Sallie R
dc.contributor.author Smith, SD
dc.contributor.author Tomaras, Georgia Doris
dc.contributor.author Wilks, AB
dc.coverage.spatial United States
dc.date.accessioned 2017-06-01T20:24:34Z
dc.date.available 2017-06-01T20:24:34Z
dc.date.issued 2013-10
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/23926338
dc.identifier JVI.01887-13
dc.identifier.uri https://hdl.handle.net/10161/14724
dc.description.abstract The design of an effective vaccine to reduce the incidence of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) via breastfeeding will require identification of protective immune responses that block postnatal virus acquisition. Natural hosts of simian immunodeficiency virus (SIV) sustain nonpathogenic infection and rarely transmit the virus to their infants despite high milk virus RNA loads. This is in contrast to HIV-infected women and SIV-infected rhesus macaques (RhMs), nonnatural hosts which exhibit higher rates of postnatal virus transmission. In this study, we compared the systemic and mucosal B cell responses of lactating, SIV-infected African green monkeys (AGMs), a natural host species, to that of SIV-infected RhMs and HIV-infected women. AGMs did not demonstrate hypergammaglobulinemia or accumulate circulating memory B cells during chronic SIV infection. Moreover, the milk of SIV-infected AGMs contained higher proportions of naive B cells than RhMs. Interestingly, AGMs exhibited robust milk and plasma Env binding antibody responses that were one to two logs higher than those in RhMs and humans and demonstrated autologous neutralizing responses in milk at 1 year postinfection. Furthermore, the plasma and milk Env gp120-binding antibody responses were equivalent to or predominant over Env gp140-binding antibody responses in AGMs, in contrast to that in RhMs and humans. The strong gp120-specific, functional antibody responses in the milk of SIV-infected AGMs may contribute to the rarity of postnatal transmission observed in natural SIV hosts.
dc.language eng
dc.relation.ispartof J Virol
dc.relation.isversionof 10.1128/JVI.01887-13
dc.subject Animals
dc.subject Antibodies, Viral
dc.subject B-Lymphocytes
dc.subject Cercopithecus aethiops
dc.subject Female
dc.subject HIV Infections
dc.subject Humans
dc.subject Macaca mulatta
dc.subject Membrane Glycoproteins
dc.subject Milk, Human
dc.subject Simian Acquired Immunodeficiency Syndrome
dc.subject Simian Immunodeficiency Virus
dc.subject Viral Envelope Proteins
dc.title Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/23926338
pubs.begin-page 11121
pubs.end-page 11134
pubs.issue 20
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Human Vaccine Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Duke Human Vaccine Institute
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Pediatrics
pubs.organisational-group Pediatrics, Infectious Diseases
pubs.organisational-group School of Medicine
pubs.organisational-group Surgery
pubs.organisational-group Surgery, Surgical Sciences
pubs.publication-status Published
pubs.volume 87
dc.identifier.eissn 1098-5514


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