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Influence of HLA-C expression level on HIV control.

dc.contributor.author Apps, R
dc.contributor.author Bosch, R
dc.contributor.author Brumme, CJ
dc.contributor.author Brumme, ZL
dc.contributor.author Buchbinder, S
dc.contributor.author Carlson, JM
dc.contributor.author Carrington, Mary
dc.contributor.author Chen, H
dc.contributor.author Deeks, SG
dc.contributor.author Del Prete, GQ
dc.contributor.author Denny, Thomas Norton
dc.contributor.author Fang, J
dc.contributor.author Fellay, J
dc.contributor.author Gao, X
dc.contributor.author Goedert, JJ
dc.contributor.author Goulder, P
dc.contributor.author Heckerman, D
dc.contributor.author John, M
dc.contributor.author Kirk, GD
dc.contributor.author Liao, W
dc.contributor.author Lifson, JD
dc.contributor.author Mallal, S
dc.contributor.author McLaren, P
dc.contributor.author Michael, NL
dc.contributor.author Moffett, A
dc.contributor.author Moody, M Anthony
dc.contributor.author Nelson, G
dc.contributor.author Pereyra, F
dc.contributor.author Qi, Y
dc.contributor.author Soderberg, Kelly
dc.contributor.author Stein, JL
dc.contributor.author Thomas, Rasmi
dc.contributor.author Walker, B
dc.contributor.author Weintrob, Amy C
dc.contributor.author Wolinsky, S
dc.contributor.author Yuki, Y
dc.contributor.author Zeng, X
dc.coverage.spatial United States
dc.date.accessioned 2017-06-01T20:35:06Z
dc.date.available 2017-06-01T20:35:06Z
dc.date.issued 2013-04-05
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/23559252
dc.identifier 340/6128/87
dc.identifier.uri https://hdl.handle.net/10161/14728
dc.description.abstract A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of individual HLA allelic effects in both African and European Americans, regardless of their distinct HLA-C frequencies and linkage relationships with HLA-B and HLA-A. Higher HLA-C expression was correlated with increased likelihood of cytotoxic T lymphocyte responses and frequency of viral escape mutation. In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease.
dc.language eng
dc.relation.ispartof Science
dc.relation.isversionof 10.1126/science.1232685
dc.subject African Americans
dc.subject Alleles
dc.subject Amino Acid Sequence
dc.subject Anti-Retroviral Agents
dc.subject Crohn Disease
dc.subject Gene Expression Regulation
dc.subject HIV
dc.subject HIV Infections
dc.subject HLA-C Antigens
dc.subject Humans
dc.subject Immunodominant Epitopes
dc.subject Molecular Sequence Data
dc.subject Mutation
dc.subject Peptide Fragments
dc.subject Polymorphism, Single Nucleotide
dc.subject T-Lymphocytes, Cytotoxic
dc.subject Viral Load
dc.title Influence of HLA-C expression level on HIV control.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/23559252
pubs.begin-page 87
pubs.end-page 91
pubs.issue 6128
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Human Vaccine Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Duke Human Vaccine Institute
pubs.organisational-group Pediatrics
pubs.organisational-group Pediatrics, Infectious Diseases
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 340
dc.identifier.eissn 1095-9203


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