Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection.
Abstract
OBJECTIVE: Different HIV-1 antigen specificities appear in sequence after HIV-1 transmission
and the immunoglobulin G (IgG) subclass responses to HIV antigens are distinct from
each other. The initial predominant IgG subclass response to HIV-1 infection consists
of IgG1 and IgG3 antibodies with a noted decline in some IgG3 antibodies during acute
HIV-1 infection. Thus, we postulate that multiple antigen-specific IgG3 responses
may serve as surrogates for the relative time since HIV-1 acquisition. DESIGN: We
determined the magnitude, peak, and half-life of HIV-1 antigen-specific IgG1 and IgG3
antibodies in 41 HIV-1-infected individuals followed longitudinally from acute infection
during the first appearance of HIV-1-specific antibodies through approximately 6 months
after infection. METHODS: We used quantitative HIV-1-binding antibody multiplex assays
and exponential decay models to estimate concentrations of IgG1 and IgG3 antibodies
to eight different HIV-1 proteins including gp140 Env, gp120 Env, gp41 Env, p66 reverse
transcriptase, p31 Integrase, Tat, Nef, and p55 Gag proteins during acute/recent HIV-1
infection. RESULTS: Among HIV-1-specific IgG3 responses, anti-gp41 IgG3 antibodies
were the first to appear. We found that anti-gp41 Env IgG3 and anti-p66 reverse transcriptase
IgG3 antibodies, in addition to anti-Gag IgG3 antibodies, each consistently and measurably
declined after acute infection, in contrast to the persistent antigen-specific IgG1
responses. CONCLUSION: The detailed measurements of the decline in multiple HIV-specific
IgG3 responses simultaneous with persistent IgG1 responses during acute and recent
HIV-1 infection could serve as markers for detection of incident HIV infection.
Type
Journal articleSubject
AdolescentAdult
Algorithms
Antibody Specificity
Antigen-Antibody Reactions
Biomarkers
Enzyme-Linked Immunosorbent Assay
Female
HIV Antigens
HIV Infections
HIV-1
Humans
Immunoglobulin G
Male
Middle Aged
Time Factors
Viral Load
Young Adult
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https://hdl.handle.net/10161/14739Published Version (Please cite this version)
10.1097/QAD.0b013e32834b348ePublication Info
Yates, Nicole L; Lucas, Judith T; Nolen, Tracy L; Vandergrift, Nathan A; Soderberg,
Kelly A; Seaton, Kelly E; ... Tomaras, Georgia D (2011). Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for
detection of incident HIV infection. AIDS, 25(17). pp. 2089-2097. 10.1097/QAD.0b013e32834b348e. Retrieved from https://hdl.handle.net/10161/14739.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Thomas Norton Denny
Professor in Medicine
Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine
Institute (DHVI), Associate Dean for Duke Research and Discovery @RTP, and a Professor
of Medicine in the Department of Medicine at Duke University Medical Center. He is
also an Affiliate Member of the Duke Global Health Institute. Previously, he served
on the Health Sector Advisory Council of the Duke University Fuquay School of Business.
Prior to joining Duke, he was an Associate Professor of Pathology, Labo
Barton Ford Haynes
Frederic M. Hanes Distinguished Professor of Medicine
Barton F. Haynes, M.D. is the Frederic M. Hanes Professor of Medicine and Immunology,
and Director of the Duke Human Vaccine Institute. Prior to leading the DHVI, Dr. Haynes
served as Chief of the Division of Rheumatology, Allergy and Clinical Immunology,
and later as Chair of the Department of Medicine. As Director of the Duke Human Vaccine
Institute, Bart Haynes is leading a team of investigators working on vaccines for
emerging infections, including tuberculosis, pandemic influenza, emergi
Georgia Doris Tomaras
Professor in Surgery
Dr. Georgia Tomaras is a tenured Professor of Surgery, Professor of Immunology, Professor
of Molecular Genetics and Microbiology and is a Fellow of the American Academy of
Microbiology (AAM) and a Fellow of the American Association for the Advancement of
Science (AAAS). Dr. Tomaras is Co-Director of the Center for Human Systems Immunology
(CHSI) Duke University and Director of the Duke Center for AIDS Research (CFAR). Her
national and international leadership roles i
Nathan A. Vandergrift
Associate Professor in Medicine
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