Telomeres and the natural lifespan limit in humans.
Repository Usage Stats
An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the 'telomeric brink', which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus, secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.
Published Version (Please cite this version)10.18632/aging.101216
Publication InfoArbeev, Konstantin; Aviv, A; Barbieri, M; Benetos, A; Berenson, GS; Chen, W; ... Yashin, Anatoli I (2017). Telomeres and the natural lifespan limit in humans. Aging (Albany NY), 9(4). pp. 1130-1142. 10.18632/aging.101216. Retrieved from http://hdl.handle.net/10161/14745.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
More InfoShow full item record
Associate Research Professor in the Social Science Research Institute
Konstantin G. Arbeev received the M.S. degree in Applied Mathematics from Moscow State University (branch in Ulyanovsk, Russia) in 1995 and the Ph.D. degree in Mathematics and Physics (specialization in Theoretical Foundations of Mathematical Modeling, Numerical Methods and Programming) from Ulyanovsk State University (Russia) in 1999. He was a post-doctoral fellow in Max Planck Institute for Demographic Research in Rostock (Germany) before moving to Duke University in 2004 to work as a Resea
Research Professor in the Social Science Research Institute
Alphabetical list of authors with Scholars@Duke profiles.