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Telomeres and the natural lifespan limit in humans.

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Date
2017-04
Authors
Steenstrup, Troels
Kark, Jeremy D
Verhulst, Simon
Thinggaard, Mikael
Hjelmborg, Jacob VB
Dalgård, Christine
Kyvik, Kirsten Ohm
Christiansen, Lene
Mangino, Massimo
Spector, Timothy D
Petersen, Inge
Kimura, Masayuki
Benetos, Athanase
Labat, Carlos
Sinnreich, Ronit
Hwang, Shih-Jen
Levy, Daniel
Hunt, Steven C
Fitzpatrick, Annette L
Chen, Wei
Berenson, Gerald S
Barbieri, Michelangela
Paolisso, Giuseppe
Gadalla, Shahinaz M
Savage, Sharon A
Christensen, Kaare
Yashin, Anatoliy I
Arbeev, Konstantin G
Aviv, Abraham
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Abstract
An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the 'telomeric brink', which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus, secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.
Type
Journal article
Subject
leukocytes
life-expectancy
longevity
maximal lifespan
sex
Permalink
https://hdl.handle.net/10161/14745
Published Version (Please cite this version)
10.18632/aging.101216
Publication Info
Steenstrup, Troels; Kark, Jeremy D; Verhulst, Simon; Thinggaard, Mikael; Hjelmborg, Jacob VB; Dalgård, Christine; ... Aviv, Abraham (2017). Telomeres and the natural lifespan limit in humans. Aging (Albany NY), 9(4). pp. 1130-1142. 10.18632/aging.101216. Retrieved from https://hdl.handle.net/10161/14745.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Arbeev

Konstantin Arbeev

Associate Research Professor in the Social Science Research Institute
Konstantin G. Arbeev received the M.S. degree in Applied Mathematics from Moscow State University (branch in Ulyanovsk, Russia) in 1995 and the Ph.D. degree in Mathematics and Physics (specialization in Theoretical Foundations of Mathematical Modeling, Numerical Methods and Programming) from Ulyanovsk State University (Russia) in 1999. He was a post-doctoral fellow in Max Planck Institute for Demographic Research in Rostock (Germany) before moving to Duke University in 2004 to work as a Resea
Yashin

Anatoli I. Yashin

Research Professor in the Social Science Research Institute
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