Show simple item record

How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.

dc.contributor.author Akushevich, Igor
dc.contributor.author Arbeev, Konstantin
dc.contributor.author Arbeeva, LS
dc.contributor.author Culminskaya, IV
dc.contributor.author Kovtun, Mikhail
dc.contributor.author Kulminski, Alexander
dc.contributor.author Li, M
dc.contributor.author Stallard, Eric
dc.contributor.author Ukraintseva, Svetlana
dc.contributor.author Wu, Dequing
dc.contributor.author Yashin, Anatoli I
dc.contributor.author Yashkin, Arseniy
dc.coverage.spatial Netherlands
dc.date.accessioned 2017-06-05T17:46:04Z
dc.date.available 2017-06-05T17:46:04Z
dc.date.issued 2016-02
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/26280653
dc.identifier 10.1007/s10522-015-9594-8
dc.identifier.uri http://hdl.handle.net/10161/14803
dc.description.abstract Increasing proportions of elderly individuals in developed countries combined with substantial increases in related medical expenditures make the improvement of the health of the elderly a high priority today. If the process of aging by individuals is a major cause of age related health declines then postponing aging could be an efficient strategy for improving the health of the elderly. Implementing this strategy requires a better understanding of genetic and non-genetic connections among aging, health, and longevity. We review progress and problems in research areas whose development may contribute to analyses of such connections. These include genetic studies of human aging and longevity, the heterogeneity of populations with respect to their susceptibility to disease and death, forces that shape age patterns of human mortality, secular trends in mortality decline, and integrative mortality modeling using longitudinal data. The dynamic involvement of genetic factors in (i) morbidity/mortality risks, (ii) responses to stresses of life, (iii) multi-morbidities of many elderly individuals, (iv) trade-offs for diseases, (v) genetic heterogeneity, and (vi) other relevant aging-related health declines, underscores the need for a comprehensive, integrated approach to analyze the genetic connections for all of the above aspects of aging-related changes. The dynamic relationships among aging, health, and longevity traits would be better understood if one linked several research fields within one conceptual framework that allowed for efficient analyses of available longitudinal data using the wealth of available knowledge about aging, health, and longevity already accumulated in the research field.
dc.language eng
dc.relation.ispartof Biogerontology
dc.relation.isversionof 10.1007/s10522-015-9594-8
dc.subject Genetic heterogeneity
dc.subject Health of the elderly
dc.subject Longitudinal data
dc.subject Pleiotropy
dc.subject Population aging
dc.subject Quadratic hazard
dc.subject Age Distribution
dc.subject Aging
dc.subject Disease Susceptibility
dc.subject Female
dc.subject Genetic Markers
dc.subject Genetic Predisposition to Disease
dc.subject Health Status
dc.subject Humans
dc.subject Incidence
dc.subject Longevity
dc.subject Male
dc.subject Models, Genetic
dc.subject Mortality
dc.subject Risk Factors
dc.subject Stress, Psychological
dc.subject Survival Rate
dc.title How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/26280653
pubs.begin-page 89
pubs.end-page 107
pubs.issue 1
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Economics
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Physics
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group Staff
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 17
dc.identifier.eissn 1573-6768


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record