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Exploring the association between melanoma and glioma risks.

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Date
2014-06
Authors
Scarbrough, Peter M
Akushevich, Igor
Wrensch, Margaret
Il'yasova, Dora
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Abstract
PURPOSE: Gliomas are one of the most fatal malignancies, with largely unknown etiology. This study examines a possible connection between glioma and melanoma, which might provide insight into gliomas' etiology. METHODS: Using data provided by the Surveillance, Epidemiology, and End Results program from 1992 to 2009, a cohort was constructed to determine the incidence rates of glioma among those who had a prior diagnosis of invasive melanoma. Glioma rates in those with prior melanoma were compared with those in the general population. RESULTS: The incidence rate of all gliomas was greater among melanoma cases than in the general population: 10.46 versus 6.13 cases per 100,000 person-years, standardized incidence ratios = 1.42 (1.22-1.62). The female excess rate was slightly greater (42%) than that among males (29%). Sensitivity analyses did not reveal evidence that radiation treatment of melanoma is responsible for the detected gap in the rates of gliomas. CONCLUSIONS: Our analysis documented increased risk of glioma among melanoma patients. Because no common environmental risk factors are identified for glioma and melanoma, it is hypothesized that a common genetic predisposition may be responsible for the detected association.
Type
Journal article
Subject
Epidemiology
Glioblastoma
Glioma
Melanoma
SEER
Adult
Aged
Cohort Studies
Female
Glioma
Humans
Incidence
Male
Melanoma
Middle Aged
Risk Factors
SEER Program
Sex Distribution
Skin Neoplasms
United States
Permalink
https://hdl.handle.net/10161/14830
Published Version (Please cite this version)
10.1016/j.annepidem.2014.02.010
Publication Info
Scarbrough, Peter M; Akushevich, Igor; Wrensch, Margaret; & Il'yasova, Dora (2014). Exploring the association between melanoma and glioma risks. Ann Epidemiol, 24(6). pp. 469-474. 10.1016/j.annepidem.2014.02.010. Retrieved from https://hdl.handle.net/10161/14830.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Igor Akushevich

Research Professor in the Social Science Research Institute
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