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    Exploring the association between melanoma and glioma risks.

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    Date
    2014-06
    Authors
    Scarbrough, Peter
    Akushevich, Igor
    Wrensch, M
    Il'yasova, D
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    Abstract
    PURPOSE: Gliomas are one of the most fatal malignancies, with largely unknown etiology. This study examines a possible connection between glioma and melanoma, which might provide insight into gliomas' etiology. METHODS: Using data provided by the Surveillance, Epidemiology, and End Results program from 1992 to 2009, a cohort was constructed to determine the incidence rates of glioma among those who had a prior diagnosis of invasive melanoma. Glioma rates in those with prior melanoma were compared with those in the general population. RESULTS: The incidence rate of all gliomas was greater among melanoma cases than in the general population: 10.46 versus 6.13 cases per 100,000 person-years, standardized incidence ratios = 1.42 (1.22-1.62). The female excess rate was slightly greater (42%) than that among males (29%). Sensitivity analyses did not reveal evidence that radiation treatment of melanoma is responsible for the detected gap in the rates of gliomas. CONCLUSIONS: Our analysis documented increased risk of glioma among melanoma patients. Because no common environmental risk factors are identified for glioma and melanoma, it is hypothesized that a common genetic predisposition may be responsible for the detected association.
    Type
    Journal article
    Subject
    Epidemiology
    Glioblastoma
    Glioma
    Melanoma
    SEER
    Adult
    Aged
    Cohort Studies
    Female
    Glioma
    Humans
    Incidence
    Male
    Melanoma
    Middle Aged
    Risk Factors
    SEER Program
    Sex Distribution
    Skin Neoplasms
    United States
    Permalink
    https://hdl.handle.net/10161/14830
    Published Version (Please cite this version)
    10.1016/j.annepidem.2014.02.010
    Publication Info
    Scarbrough, Peter; Akushevich, Igor; Wrensch, M; & Il'yasova, D (2014). Exploring the association between melanoma and glioma risks. Ann Epidemiol, 24(6). pp. 469-474. 10.1016/j.annepidem.2014.02.010. Retrieved from https://hdl.handle.net/10161/14830.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    Igor Akushevich

    Associate Research Professor in the Social Science Research Institute
    Open Access

    Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

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