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Morbidity risks among older adults with pre-existing age-related diseases.

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Date
2013-12
Authors
Akushevich, Igor
Kravchenko, Julia
Ukraintseva, Svetlana
Arbeev, Konstantin
Kulminski, Alexander
Yashin, Anatoliy I
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Abstract
Multi-morbidity is common among older adults; however, for many aging-related diseases there is no information for U.S. elderly population on how earlier-manifested disease affects the risk of another disease manifested later during patient's lifetime. Quantitative evaluation of risks of cancer and non-cancer diseases for older adults with pre-existing conditions is performed using the Surveillance, Epidemiology, and End Results (SEER) Registry data linked to the Medicare Files of Service Use (MFSU). Using the SEER-Medicare data containing individual records for 2,154,598 individuals, we empirically evaluated age patterns of incidence of age-associated diseases diagnosed after the onset of earlier manifested disease and compared these patterns with those in general population. Individual medical histories were reconstructed using information on diagnoses coded in MFSU, dates of medical services/procedures, and Medicare enrollment/disenrollment. More than threefold increase of subsequent diseases risk was observed for 15 disease pairs, majority of them were i) diseases of the same organ and/or system (e.g., Parkinson disease for patients with Alzheimer disease, HR=3.77, kidney cancer for patients with renal failure, HR=3.28) or ii) disease pairs with primary diseases being fast-progressive cancers (i.e., lung, kidney, and pancreas), e.g., ulcer (HR=4.68) and melanoma (HR=4.15) for patients with pancreatic cancer. Lower risk of subsequent disease was registered for 20 disease pairs, mostly among patients with Alzheimer's or Parkinson's disease, e.g., decreased lung cancer risk among patients with Alzheimer's (HR=0.64) and Parkinson's (HR=0.60) disease. Synergistic and antagonistic dependences in geriatric disease risks were observed among US elderly confirming known and detecting new associations of wide spectrum of age-associated diseases. The results can be used in optimization of screening, prevention and treatment strategies of chronic diseases among U.S. elderly population.
Type
Journal article
Subject
Aging
Chronic disease onset
Comorbidity
Dependent risks
Geriatric disease
Medicare
Age Distribution
Age Factors
Aged
Aged, 80 and over
Aging
Chronic Disease
Comorbidity
Disease Susceptibility
Female
Humans
Incidence
Male
Medicare
Middle Aged
Proportional Hazards Models
Risk Assessment
Risk Factors
SEER Program
Time Factors
United States
Permalink
https://hdl.handle.net/10161/14832
Published Version (Please cite this version)
10.1016/j.exger.2013.09.005
Publication Info
Akushevich, Igor; Kravchenko, Julia; Ukraintseva, Svetlana; Arbeev, Konstantin; Kulminski, Alexander; & Yashin, Anatoliy I (2013). Morbidity risks among older adults with pre-existing age-related diseases. Exp Gerontol, 48(12). pp. 1395-1401. 10.1016/j.exger.2013.09.005. Retrieved from https://hdl.handle.net/10161/14832.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Igor Akushevich

Research Professor in the Social Science Research Institute
Arbeev

Konstantin Arbeev

Associate Research Professor in the Social Science Research Institute
Konstantin G. Arbeev received the M.S. degree in Applied Mathematics from Moscow State University (branch in Ulyanovsk, Russia) in 1995 and the Ph.D. degree in Mathematics and Physics (specialization in Theoretical Foundations of Mathematical Modeling, Numerical Methods and Programming) from Ulyanovsk State University (Russia) in 1999. He was a post-doctoral fellow in Max Planck Institute for Demographic Research in Rostock (Germany) before moving to Duke University in 2004 to work as a Resea
Kulminski

Alexander Kulminski

Research Professor in the Social Science Research Institute
Ukraintseva

Svetlana Ukraintseva

Associate Research Professor in the Social Science Research Institute
Dr. Ukraintseva studies causes of human aging and related decline in resilience, to identify genetic and other factors responsible for the increase in mortality risk with age eventually limiting longevity. She explores complex relationships, including trade-offs, between physiological aging-changes and risks of major diseases (with emphasis on Alzheimer’s and cancer), as well as survival, to find new genetic and other targets for anti-aging interventions and disease prevention. S
Yashin

Anatoli I. Yashin

Research Professor in the Social Science Research Institute
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