Modeling hematopoietic system response caused by chronic exposure to ionizing radiation.
Abstract
A new model of the hematopoietic system response in humans chronically exposed to
ionizing radiation describes the dynamics of the hematopoietic stem cell compartment
as well as the dynamics of each of the four blood cell types (lymphocytes, neutrophiles,
erythrocytes, and platelets). The required model parameters were estimated based on
available results of human and experimental animal studies. They include the steady-state
number of hematopoietic stem cells and peripheral blood cell lines in an unexposed
organism, amplification parameters for each blood line, parameters describing proliferation
and apoptosis, parameters of feedback functions regulating the steady-state numbers,
and characteristics of radiosensitivity related to cell death and non-lethal cell
damage. The model predictions were tested using data on hematological measurements
(e.g., blood counts) performed in 1950-1956 in the Techa River residents chronically
exposed to ionizing radiation since 1949. The suggested model of hematopoiesis is
capable of describing experimental findings in the Techa River Cohort, including:
(1) slopes of the dose-effect curves reflecting the inhibition of hematopoiesis due
to chronic ionizing radiation, (2) delay in effect of chronic exposure and accumulated
character of the effect, and (3) dose-rate patterns for different cytopenic states
(e.g., leukopenia, thrombocytopenia).
Type
Journal articleSubject
Blood PlateletsComputer Simulation
Dose-Response Relationship, Radiation
Erythrocytes
Feedback
Hematopoiesis
Hematopoietic Stem Cells
Hematopoietic System
Humans
Lymphocytes
Models, Biological
Neutrophils
Radiation Injuries
Radiation Tolerance
Radiation, Ionizing
Stochastic Processes
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https://hdl.handle.net/10161/14854Published Version (Please cite this version)
10.1007/s00411-011-0351-3Publication Info
Akushevich, Igor V; Veremeyeva, Galina A; Dimov, Georgy P; Ukraintseva, Svetlana V;
Arbeev, Konstantin G; Akleyev, Alexander V; & Yashin, Anatoly I (2011). Modeling hematopoietic system response caused by chronic exposure to ionizing radiation.
Radiat Environ Biophys, 50(2). pp. 299-311. 10.1007/s00411-011-0351-3. Retrieved from https://hdl.handle.net/10161/14854.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Igor Akushevich
Research Professor in the Social Science Research Institute
Konstantin Arbeev
Associate Research Professor in the Social Science Research Institute
Konstantin G. Arbeev received the M.S. degree in Applied Mathematics from Moscow State
University (branch in Ulyanovsk, Russia) in 1995 and the Ph.D. degree in Mathematics
and Physics (specialization in Theoretical Foundations of Mathematical Modeling, Numerical
Methods and Programming) from Ulyanovsk State University (Russia) in 1999. He was
a post-doctoral fellow in Max Planck Institute for Demographic Research in Rostock
(Germany) before moving to Duke University in 2004 to work as a Resea
Svetlana Ukraintseva
Associate Research Professor in the Social Science Research Institute
Dr. Ukraintseva studies causes of human aging and related decline in resilience, to
identify genetic and other factors responsible for the increase in mortality risk
with age eventually limiting longevity. She explores complex relationships, including
trade-offs, between physiological aging-changes and risks of major diseases (with
emphasis on Alzheimer’s and cancer), as well as survival, to find new genetic and
other targets for anti-aging interventions and disease prevention. S
Anatoli I. Yashin
Research Professor in the Social Science Research Institute
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