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Early hematopoietic effects of chronic radiation exposure in humans.

dc.contributor.author Akleyev, AV
dc.contributor.author Akushevich, Igor
dc.contributor.author Dimov, GP
dc.contributor.author Ukraintseva, Svetlana
dc.contributor.author Varfolomeyeva, TA
dc.contributor.author Veremeyeva, Galina A
dc.contributor.author Yashin, Anatoli I
dc.coverage.spatial United States
dc.date.accessioned 2017-06-06T18:05:06Z
dc.date.available 2017-06-06T18:05:06Z
dc.date.issued 2010-09
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/20699694
dc.identifier 00004032-201009000-00008
dc.identifier.uri https://hdl.handle.net/10161/14860
dc.description.abstract The major goal of this study is to investigate and quantitatively describe the nature of the relationship between the characteristics of chronic exposure to ionizing radiation and specific patterns of hematopoiesis reduction. The study is based on about 3,200 hemograms taken for inhabitants of the Techa riverside villages over the years 1951-1956, i.e., the period characterized by a gradual decrease in dose rates. The mean cumulative red bone marrow dose was 333.6 + or - 4.6 mGy. The approach to statistical analyses involved both empirical methods and modeling (generalized linear models and logistic regressions). The results of the analyses highlighted a gradual increase in the frequency of cytopenias with dose rate. The impact of exposure on hematopoiesis reduction patterns was found to be more substantial than that of age and health status. Dose rates resulting in a two-fold increase in the frequency of cytopenias have been estimated.
dc.language eng
dc.relation.ispartof Health Phys
dc.relation.isversionof 10.1097/HP.0b013e3181c2f315
dc.subject Age Factors
dc.subject Blood Cell Count
dc.subject Blood Cells
dc.subject Bone Marrow
dc.subject Cohort Studies
dc.subject Environmental Exposure
dc.subject Hematopoiesis
dc.subject Humans
dc.subject Linear Energy Transfer
dc.subject Logistic Models
dc.subject Middle Aged
dc.subject Plutonium
dc.subject Radiation Dosage
dc.subject Radiation Injuries
dc.subject Retrospective Studies
dc.subject Rivers
dc.subject Russia
dc.subject Time Factors
dc.title Early hematopoietic effects of chronic radiation exposure in humans.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/20699694
pubs.begin-page 330
pubs.end-page 336
pubs.issue 3
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Physics
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group Staff
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 99
dc.identifier.eissn 1538-5159


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