Early hematopoiesis inhibition under chronic radiation exposure in humans.
Abstract
The major goal of this study was to identify and quantitatively describe the association
between the characteristics of chronic (low-dose rate) exposure to (low LET) ionizing
radiation and cellularity of peripheral blood cell lines. About 3,200 hemograms (i.e.,
spectra of blood counts) obtained over the years of maximal exposure to ionizing radiation
(1950-1956) for inhabitants of the Techa River were used in analyses. The mean cumulative
red bone marrow dose (with standard errors), calculated using Techa River Dosimetry
System-2000, was 333.6 +/- 4.6 mGy (SD = 259.9 mGy, max = 1151 mGy) to the year 1956.
The statistical approach included both empirical methods for estimating frequencies
of cytopenic states of the investigated blood cell lines (e.g. neutrophile, platelets,
erythrocyte, etc.), and regression methods, including generalized linear models and
logistic regressions which allowed taking into account confounding factors (e.g.,
attained age, age at maximal exposure, presence of concomitant diseases, and demographic
characteristics). The results of the analyses demonstrated hematopoiesis inhibition
manifested by a decrease in peripheral blood cellularity and an increase in the frequency
of cytopenia in all blood cell lines (leukocytes, including lymphocytes, monocytes,
neutrophiles, as well as platelets and erythrocytes). The intensity of hematopoiesis
inhibition in the period of maximal exposures is determined by the combined influence
of the dose rate and cumulative dose. The contribution of specific confounding factors
was quantified and shown to be much less important than dose characteristics. The
best predictor among dose characteristics was identified for each blood cell line.
A 2-fold increase in dose rate is assumed to be a characteristic of radiosensitivity
and a quantitative characteristic of the effect.
Type
Journal articleSubject
Blood Cell CountBone Marrow
Cell Line
Dose-Response Relationship, Radiation
Environmental Exposure
Female
Hematopoiesis
Humans
Leukocytes, Mononuclear
Male
Middle Aged
Radiation Dosage
Retrospective Studies
Time Factors
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https://hdl.handle.net/10161/14861Published Version (Please cite this version)
10.1007/s00411-010-0269-1Publication Info
Akleyev, Alexander V; Akushevich, Igor V; Dimov, Georgy P; Veremeyeva, Galina A; Varfolomeyeva,
Tatyana A; Ukraintseva, Svetlana V; & Yashin, Anatoly I (2010). Early hematopoiesis inhibition under chronic radiation exposure in humans. Radiat Environ Biophys, 49(2). pp. 281-291. 10.1007/s00411-010-0269-1. Retrieved from https://hdl.handle.net/10161/14861.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Igor Akushevich
Research Professor in the Social Science Research Institute
Svetlana Ukraintseva
Associate Research Professor in the Social Science Research Institute
Dr. Ukraintseva studies causes of human aging and related decline in resilience, to
identify genetic and other factors responsible for the increase in mortality risk
with age eventually limiting longevity. She explores complex relationships, including
trade-offs, between physiological aging-changes and risks of major diseases (with
emphasis on Alzheimer’s and cancer), as well as survival, to find new genetic and
other targets for anti-aging interventions and disease prevention. S
Anatoli I. Yashin
Research Professor in the Social Science Research Institute
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