dc.contributor.author |
Akleyev, Alexander V |
|
dc.contributor.author |
Akushevich, Igor V |
|
dc.contributor.author |
Dimov, Georgy P |
|
dc.contributor.author |
Veremeyeva, Galina A |
|
dc.contributor.author |
Varfolomeyeva, Tatyana A |
|
dc.contributor.author |
Ukraintseva, Svetlana V |
|
dc.contributor.author |
Yashin, Anatoly I |
|
dc.coverage.spatial |
Germany |
|
dc.date.accessioned |
2017-06-06T18:05:55Z |
|
dc.date.available |
2017-06-06T18:05:55Z |
|
dc.date.issued |
2010-05 |
|
dc.identifier |
https://www.ncbi.nlm.nih.gov/pubmed/20340030 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/14861 |
|
dc.description.abstract |
The major goal of this study was to identify and quantitatively describe the association
between the characteristics of chronic (low-dose rate) exposure to (low LET) ionizing
radiation and cellularity of peripheral blood cell lines. About 3,200 hemograms (i.e.,
spectra of blood counts) obtained over the years of maximal exposure to ionizing radiation
(1950-1956) for inhabitants of the Techa River were used in analyses. The mean cumulative
red bone marrow dose (with standard errors), calculated using Techa River Dosimetry
System-2000, was 333.6 +/- 4.6 mGy (SD = 259.9 mGy, max = 1151 mGy) to the year 1956.
The statistical approach included both empirical methods for estimating frequencies
of cytopenic states of the investigated blood cell lines (e.g. neutrophile, platelets,
erythrocyte, etc.), and regression methods, including generalized linear models and
logistic regressions which allowed taking into account confounding factors (e.g.,
attained age, age at maximal exposure, presence of concomitant diseases, and demographic
characteristics). The results of the analyses demonstrated hematopoiesis inhibition
manifested by a decrease in peripheral blood cellularity and an increase in the frequency
of cytopenia in all blood cell lines (leukocytes, including lymphocytes, monocytes,
neutrophiles, as well as platelets and erythrocytes). The intensity of hematopoiesis
inhibition in the period of maximal exposures is determined by the combined influence
of the dose rate and cumulative dose. The contribution of specific confounding factors
was quantified and shown to be much less important than dose characteristics. The
best predictor among dose characteristics was identified for each blood cell line.
A 2-fold increase in dose rate is assumed to be a characteristic of radiosensitivity
and a quantitative characteristic of the effect.
|
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartof |
Radiat Environ Biophys |
|
dc.relation.isversionof |
10.1007/s00411-010-0269-1 |
|
dc.subject |
Blood Cell Count |
|
dc.subject |
Bone Marrow |
|
dc.subject |
Cell Line |
|
dc.subject |
Dose-Response Relationship, Radiation |
|
dc.subject |
Environmental Exposure |
|
dc.subject |
Female |
|
dc.subject |
Hematopoiesis |
|
dc.subject |
Humans |
|
dc.subject |
Leukocytes, Mononuclear |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Radiation Dosage |
|
dc.subject |
Retrospective Studies |
|
dc.subject |
Time Factors |
|
dc.title |
Early hematopoiesis inhibition under chronic radiation exposure in humans. |
|
dc.type |
Journal article |
|
duke.contributor.id |
Akushevich, Igor V|0285458 |
|
duke.contributor.id |
Ukraintseva, Svetlana V|0314469 |
|
duke.contributor.id |
Yashin, Anatoly I|0115822 |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/20340030 |
|
pubs.begin-page |
281 |
|
pubs.end-page |
291 |
|
pubs.issue |
2 |
|
pubs.organisational-group |
Center for Population Health & Aging |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Cancer Institute |
|
pubs.organisational-group |
Duke Population Research Center |
|
pubs.organisational-group |
Duke Population Research Institute |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Institutes and Provost's Academic Units |
|
pubs.organisational-group |
Physics |
|
pubs.organisational-group |
Sanford School of Public Policy |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
Social Science Research Institute |
|
pubs.organisational-group |
Staff |
|
pubs.organisational-group |
Trinity College of Arts & Sciences |
|
pubs.organisational-group |
University Institutes and Centers |
|
pubs.publication-status |
Published |
|
pubs.volume |
49 |
|
dc.identifier.eissn |
1432-2099 |
|