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Early hematopoiesis inhibition under chronic radiation exposure in humans.

dc.contributor.author Akleyev, AV
dc.contributor.author Akushevich, Igor
dc.contributor.author Dimov, GP
dc.contributor.author Ukraintseva, Svetlana
dc.contributor.author Varfolomeyeva, TA
dc.contributor.author Veremeyeva, Galina A
dc.contributor.author Yashin, Anatoli I
dc.coverage.spatial Germany
dc.date.accessioned 2017-06-06T18:05:55Z
dc.date.available 2017-06-06T18:05:55Z
dc.date.issued 2010-05
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/20340030
dc.identifier.uri http://hdl.handle.net/10161/14861
dc.description.abstract The major goal of this study was to identify and quantitatively describe the association between the characteristics of chronic (low-dose rate) exposure to (low LET) ionizing radiation and cellularity of peripheral blood cell lines. About 3,200 hemograms (i.e., spectra of blood counts) obtained over the years of maximal exposure to ionizing radiation (1950-1956) for inhabitants of the Techa River were used in analyses. The mean cumulative red bone marrow dose (with standard errors), calculated using Techa River Dosimetry System-2000, was 333.6 +/- 4.6 mGy (SD = 259.9 mGy, max = 1151 mGy) to the year 1956. The statistical approach included both empirical methods for estimating frequencies of cytopenic states of the investigated blood cell lines (e.g. neutrophile, platelets, erythrocyte, etc.), and regression methods, including generalized linear models and logistic regressions which allowed taking into account confounding factors (e.g., attained age, age at maximal exposure, presence of concomitant diseases, and demographic characteristics). The results of the analyses demonstrated hematopoiesis inhibition manifested by a decrease in peripheral blood cellularity and an increase in the frequency of cytopenia in all blood cell lines (leukocytes, including lymphocytes, monocytes, neutrophiles, as well as platelets and erythrocytes). The intensity of hematopoiesis inhibition in the period of maximal exposures is determined by the combined influence of the dose rate and cumulative dose. The contribution of specific confounding factors was quantified and shown to be much less important than dose characteristics. The best predictor among dose characteristics was identified for each blood cell line. A 2-fold increase in dose rate is assumed to be a characteristic of radiosensitivity and a quantitative characteristic of the effect.
dc.language eng
dc.relation.ispartof Radiat Environ Biophys
dc.relation.isversionof 10.1007/s00411-010-0269-1
dc.subject Blood Cell Count
dc.subject Bone Marrow
dc.subject Cell Line
dc.subject Dose-Response Relationship, Radiation
dc.subject Environmental Exposure
dc.subject Female
dc.subject Hematopoiesis
dc.subject Humans
dc.subject Leukocytes, Mononuclear
dc.subject Male
dc.subject Middle Aged
dc.subject Radiation Dosage
dc.subject Retrospective Studies
dc.subject Time Factors
dc.title Early hematopoiesis inhibition under chronic radiation exposure in humans.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/20340030
pubs.begin-page 281
pubs.end-page 291
pubs.issue 2
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Physics
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group Staff
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 49
dc.identifier.eissn 1432-2099


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