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Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.

dc.contributor.author Arbeev, Konstantin
dc.contributor.author Barmada, M
dc.contributor.author Christensen, Kaare
dc.contributor.author Kulminski, Alexander
dc.contributor.author Miljkovic, I
dc.contributor.author Stallard, Eric
dc.contributor.author Yashin, Anatoli I
dc.coverage.spatial United States
dc.date.accessioned 2017-06-06T19:21:54Z
dc.date.available 2017-06-06T19:21:54Z
dc.date.issued 2013-07
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/23213029
dc.identifier gls243
dc.identifier.uri https://hdl.handle.net/10161/14870
dc.description.abstract This study focuses on the participants of the Long Life Family Study to elucidate whether biogenetic mechanisms underlying relationships among heritable complex phenotypes in parents function in the same way for the same phenotypes in their children. Our results reveal 3 characteristic groups of relationships among phenotypes in parents and children. One group composed of 3 pairs of phenotypes confirms that associations among some phenotypes can be explained by the same biogenetic mechanisms working in parents and children. Two other groups including 9 phenotype pairs show that this is not a common rule. Our findings suggest that biogenetic mechanisms underlying relationships among different phenotypes, even if they are causally related, can function differently in successive generations or in different age groups of biologically related individuals. The results suggest that the role of aging-related processes in changing environment may be conceptually underestimated in current genetic association studies using genome wide resources.
dc.language eng
dc.relation.ispartof J Gerontol A Biol Sci Med Sci
dc.relation.isversionof 10.1093/gerona/gls243
dc.subject Aging
dc.subject Disease
dc.subject Genetics of healthspan
dc.subject Heritability
dc.subject Longevity regulation
dc.subject Adult Children
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Aging
dc.subject Environment
dc.subject Epigenesis, Genetic
dc.subject Female
dc.subject Genetic Predisposition to Disease
dc.subject Genotype
dc.subject Humans
dc.subject Longevity
dc.subject Male
dc.subject Middle Aged
dc.subject Parents
dc.subject Phenotype
dc.title Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/23213029
pubs.begin-page 760
pubs.end-page 768
pubs.issue 7
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group Staff
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 68
dc.identifier.eissn 1758-535X


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