How genes influence life span: the biodemography of human survival.
Abstract
BACKGROUND: In genome-wide association studies (GWAS) of human life span, none of
the genetic variants has reached the level of genome-wide statistical significance.
The roles of such variants in life span regulation remain unclear. DATA AND METHOD:
A biodemographic analyses was done of genetic regulation of life span using data on
low-significance longevity alleles selected in the earlier GWAS of the original Framingham
cohort. RESULTS: Age-specific survival curves considered as functions of the number
of longevity alleles exhibit regularities known in demography as "rectangularization"
of survival curves. The presence of such pattern confirms observations from experimental
studies that regulation of life span involves genes responsible for stress resistance.
CONCLUSION: Biodemographic analyses could provide important information about the
properties of genes affecting phenotypic traits.
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https://hdl.handle.net/10161/14874Published Version (Please cite this version)
10.1089/rej.2011.1290Publication Info
(2012). How genes influence life span: the biodemography of human survival. Rejuvenation Res, 15(4). pp. 374-380. 10.1089/rej.2011.1290. Retrieved from https://hdl.handle.net/10161/14874.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Konstantin Arbeev
Associate Research Professor in the Social Science Research Institute
Konstantin G. Arbeev received the M.S. degree in Applied Mathematics from Moscow State
University (branch in Ulyanovsk, Russia) in 1995 and the Ph.D. degree in Mathematics
and Physics (specialization in Theoretical Foundations of Mathematical Modeling, Numerical
Methods and Programming) from Ulyanovsk State University (Russia) in 1999. He was
a post-doctoral fellow in Max Planck Institute for Demographic Research in Rostock
(Germany) before moving to Duke University in 2004 to work as a Resea
Kenneth C. Land
John Franklin Crowell Professor Emeritus of Sociology
I received my Ph.D. in sociology and mathematics from
the University of Texas at Austin in 1969. After a year of
postdoctoral study in mathematical statistics at
Columbia University in New York City, I taught there
and was a member of the staff of the Russell Sage
Foundation for three years. I then was successively a
member of the faculties of the University of Illinois at
Urbana Champaign and the University of Texas at Austin
before joining the Duke Sociology Department as
Chairman in
Patrick J. Eric Stallard
Research Professor in the SocialScience Research Institute
I am a Research Professor in the Social Science Research Institute and Co-Director
of the Biodemography of Aging Research Unit at Duke University. I am a Member of the
American Academy of Actuaries, a Fellow of the Conference of Consulting Actuaries,
and an Associate of the Society of Actuaries. My research expertise includes modeling
and forecasting for biomedical demography and health/LTC actuarial practice. My expertise
in these areas is evidenced by my five books, five monographs, 151 sci
Svetlana Ukraintseva
Associate Research Professor in the Social Science Research Institute
Dr. Ukraintseva's research interests include understanding of the genetic and other
causes of human aging and longevity, with emphasis on factors responsible for the
decline in physical resilience with age that lead to the increase in mortality risk
eventually limiting longevity. She uses data from large human studies containing genetic
and phenotypic information on thousands of individuals, to explore the relationships
(including trade-off-like) between physical senescence and vulnera
Dequing Wu
Research Scientist, Senior
Anatoli I. Yashin
Research Professor in the Social Science Research Institute
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