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How genes influence life span: the biodemography of human survival.

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Date
2012-08
Authors
Yashin, Anatoliy I
Wu, Deqing
Arbeev, Konstantin G
Stallard, Eric
Land, Kenneth C
Ukraintseva, Svetlana V
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Abstract
BACKGROUND: In genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain unclear. DATA AND METHOD: A biodemographic analyses was done of genetic regulation of life span using data on low-significance longevity alleles selected in the earlier GWAS of the original Framingham cohort. RESULTS: Age-specific survival curves considered as functions of the number of longevity alleles exhibit regularities known in demography as "rectangularization" of survival curves. The presence of such pattern confirms observations from experimental studies that regulation of life span involves genes responsible for stress resistance. CONCLUSION: Biodemographic analyses could provide important information about the properties of genes affecting phenotypic traits.
Type
Journal article
Subject
Aging
Alleles
Cohort Studies
Demography
Genome-Wide Association Study
Humans
Longevity
Phenotype
Permalink
https://hdl.handle.net/10161/14874
Published Version (Please cite this version)
10.1089/rej.2011.1290
Publication Info
Yashin, Anatoliy I; Wu, Deqing; Arbeev, Konstantin G; Stallard, Eric; Land, Kenneth C; & Ukraintseva, Svetlana V (2012). How genes influence life span: the biodemography of human survival. Rejuvenation Res, 15(4). pp. 374-380. 10.1089/rej.2011.1290. Retrieved from https://hdl.handle.net/10161/14874.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Arbeev

Konstantin Arbeev

Associate Research Professor in the Social Science Research Institute
Konstantin G. Arbeev received the M.S. degree in Applied Mathematics from Moscow State University (branch in Ulyanovsk, Russia) in 1995 and the Ph.D. degree in Mathematics and Physics (specialization in Theoretical Foundations of Mathematical Modeling, Numerical Methods and Programming) from Ulyanovsk State University (Russia) in 1999. He was a post-doctoral fellow in Max Planck Institute for Demographic Research in Rostock (Germany) before moving to Duke University in 2004 to work as a Resea
Land

Kenneth C. Land

John Franklin Crowell Distinguished Professor Emeritus of Sociology
I received my Ph.D. in sociology and mathematics from the University of Texas at Austin in 1969. After a year of postdoctoral study in mathematical statistics at Columbia University in New York City, I taught there and was a member of the staff of the Russell Sage Foundation for three years. I then was successively a member of the faculties of the University of Illinois at Urbana Champaign and the University of Texas at Austin before joining the Duke Sociology Department as Chairman in
Ukraintseva

Svetlana Ukraintseva

Associate Research Professor in the Social Science Research Institute
Dr. Ukraintseva studies causes of human aging and related decline in resilience, to identify genetic and other factors responsible for the increase in mortality risk with age eventually limiting longevity. She explores complex relationships, including trade-offs, between physiological aging-changes and risks of major diseases (with emphasis on Alzheimer’s and cancer), as well as survival, to find new genetic and other targets for anti-aging interventions and disease prevention. S
Wu

Dequing Wu

Research Scientist, Senior
Yashin

Anatoli I. Yashin

Research Professor in the Social Science Research Institute
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