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Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.

dc.contributor.author Arbeev, Konstantin
dc.contributor.author Aviv, A
dc.contributor.author Hunt, SC
dc.contributor.author Kimura, M
dc.contributor.author Yashin, Anatoli I
dc.coverage.spatial Ireland
dc.date.accessioned 2017-06-07T19:01:31Z
dc.date.available 2017-06-07T19:01:31Z
dc.date.issued 2011-04
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/21354438
dc.identifier S0047-6374(11)00026-1
dc.identifier.uri https://hdl.handle.net/10161/14876
dc.description.abstract Recent studies have reported that leukocyte telomere length (LTL) is longer in offspring of older fathers. Longer telomeres might increase cancer risk. We examined the relation of father's age at the birth of the offspring (FAB) with LTL in the offspring in 2177 participants of the Family Heart Study and the probability of developing breast cancer in 1405 women from the Framingham Heart Study (offspring cohort). For each year of increase in FAB (adjusted for mother's age at birth), LTLs in the daughters and sons were longer by 19.4bp and 12.2bp, respectively (p<0.0001). Daughters of older fathers were less likely to stay free of breast cancer compared to daughters of younger fathers in empirical (p=0.014) and Cox regression analyses (p=0.0012) adjusted for relevant covariates. We conclude that older fathers endow their offspring with a longer LTL and their daughters with increased susceptibility to breast cancer. These independent observations cannot provide evidence for a causal relationship, mediated by telomere length, between FAB and increased breast cancer risk in daughters. However, with couples delaying having children in today's society, studies exploring the LTL association with increased breast cancer risk in daughters of older fathers might be timely and relevant.
dc.language eng
dc.relation.ispartof Mech Ageing Dev
dc.relation.isversionof 10.1016/j.mad.2011.02.004
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Breast Neoplasms
dc.subject Cohort Studies
dc.subject Female
dc.subject Genetic Predisposition to Disease
dc.subject Humans
dc.subject Leukocytes
dc.subject Male
dc.subject Middle Aged
dc.subject Paternal Age
dc.subject Proportional Hazards Models
dc.subject Risk
dc.subject Telomere
dc.title Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/21354438
pubs.begin-page 149
pubs.end-page 153
pubs.issue 4
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group Staff
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 132
dc.identifier.eissn 1872-6216


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