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Leukocyte telomere length is associated with disability in older u.s. Population.

dc.contributor.author Arbeev, Konstantin
dc.contributor.author Martin, GM
dc.contributor.author Oshima, J
dc.contributor.author Rabinovitch, PS
dc.contributor.author Risques, RA
dc.contributor.author Ukraintseva, Svetlana
dc.contributor.author Yashin, Anatoli I
dc.coverage.spatial United States
dc.date.accessioned 2017-06-07T19:31:49Z
dc.date.available 2017-06-07T19:31:49Z
dc.date.issued 2010-07
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/20579170
dc.identifier JGS2948
dc.identifier.uri http://hdl.handle.net/10161/14880
dc.description.abstract OBJECTIVES: To determine whether mean leukocyte telomere length (LTL) serves as a biomarker of disability assessed according to activities of daily living (ADLs) and what factors may modify this relationship. DESIGN: Retrospective cross-sectional study. SETTING: A subset of the National Long Term Care Survey (NTLCS), a Medicare-based U.S. population longitudinal study focused on trends of overall health and functional status in older adults. PARTICIPANTS: Six hundred and twenty-four individuals from the 1999 wave of the NTLCS cohort. MEASUREMENTS: Relative LTL determined according to quantitative polymerase chain reaction. LTL has previously been shown to correlate with common age-related disorders and mortality, as well as with socioeconomic status. RESULTS: A sex difference in LTL was observed but not age-dependent shortening or association with socioeconomic status. LTL was associated with disability and functional status assessed according to ADLs. The association between ADLs and LTL was stronger in subjects without diabetes mellitus, whereas associations were not seen when only subjects with diabetes mellitus were analyzed. Associations between LTL and cardiovascular disease (CVD) and cancer were also present in the group without diabetes mellitus but not in the group with diabetes mellitus. CONCLUSION: These findings support the concept that LTL is a biomarker of overall well-being that is predictive of disability of older individuals in the U.S. population. Diabetes mellitus plays an important role as a modifier of the association between LTL and disability, CVD, and cancer. These associations have clinical implications because of the potential predictive value of LTL and deserve further investigation.
dc.language eng
dc.relation.ispartof J Am Geriatr Soc
dc.relation.isversionof 10.1111/j.1532-5415.2010.02948.x
dc.subject Activities of Daily Living
dc.subject Age Factors
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Biomarkers
dc.subject Cross-Sectional Studies
dc.subject Disability Evaluation
dc.subject Female
dc.subject Geriatric Assessment
dc.subject Humans
dc.subject Leukocytes
dc.subject Male
dc.subject Predictive Value of Tests
dc.subject Retrospective Studies
dc.subject Sex Factors
dc.subject Socioeconomic Factors
dc.subject Telomere
dc.title Leukocyte telomere length is associated with disability in older u.s. Population.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/20579170
pubs.begin-page 1289
pubs.end-page 1298
pubs.issue 7
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group Staff
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 58
dc.identifier.eissn 1532-5415


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