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Heritability estimates of endophenotypes of long and health life: the Long Life Family Study.

dc.contributor.author Arbeev, Konstantin
dc.contributor.author Barr, G
dc.contributor.author Christensen, Kaare
dc.contributor.author Fallin, MD
dc.contributor.author Kammerer, CM
dc.contributor.author Matteini, AM
dc.contributor.author Mayeux, R
dc.contributor.author Newman, Anne B
dc.contributor.author Schupf, N
dc.contributor.author Walston, JD
dc.contributor.author Yashin, Anatoli I
dc.coverage.spatial United States
dc.date.accessioned 2017-06-07T19:37:50Z
dc.date.available 2017-06-07T19:37:50Z
dc.date.issued 2010-12
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/20813793
dc.identifier glq154
dc.identifier.uri http://hdl.handle.net/10161/14882
dc.description.abstract BACKGROUND: Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span. METHODS: As part of phenotype development efforts for the Long Life Family Study, endophenotypes that represent exceptional survival were identified and heritability estimates were calculated. Principal components (PCs) analysis was carried out using 28 physiologic measurements from five trait domains (cardiovascular, cognition, physical function, pulmonary, and metabolic). RESULTS: The five most dominant PCs accounted for 50% of underlying trait variance. The first PC (PC1), which consisted primarily of poor pulmonary and physical function, represented 14.3% of the total variance and had an estimated heritability of 39%. PC2 consisted of measures of good metabolic and cardiovascular function with an estimated heritability of 27%. PC3 was made up of cognitive measures (h(2) = 36%). PC4 and PC5 contained measures of blood pressure and cholesterol, respectively (h(2) = 25% and 16%). CONCLUSIONS: These PCs analysis-derived endophenotypes may be used in genetic association studies to help identify underlying genetic mechanisms that drive exceptional survival in this and other populations.
dc.language eng
dc.relation.ispartof J Gerontol A Biol Sci Med Sci
dc.relation.isversionof 10.1093/gerona/glq154
dc.subject Cardiovascular Physiological Phenomena
dc.subject Cholesterol, HDL
dc.subject Cognition
dc.subject Cohort Studies
dc.subject Endophenotypes
dc.subject Forced Expiratory Volume
dc.subject Genetic Variation
dc.subject Hand Strength
dc.subject Health Status
dc.subject Humans
dc.subject Longevity
dc.subject Lung
dc.subject Metabolism
dc.subject Motor Activity
dc.subject National Institute on Aging (U.S.)
dc.subject Principal Component Analysis
dc.subject Quantitative Trait, Heritable
dc.subject United States
dc.subject Waist Circumference
dc.title Heritability estimates of endophenotypes of long and health life: the Long Life Family Study.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/20813793
pubs.begin-page 1375
pubs.end-page 1379
pubs.issue 12
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group Staff
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 65
dc.identifier.eissn 1758-535X


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